• The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice 

      San Román Aberasturi, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Lasarte, Juan José; Grilló Dolset, María Jesús; Garrido, Victoria Upna; Muñoz Álvaro, Pilar María; Arribillaga, Laura; García Martínez, Begoña Upna; Andrés, Ximena de; Zabaleta, Virginia Upna; Mansilla, Cristina; Farrán Blanch, Inmaculada Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered with bacteria has not been assessed. Here, we investigated the adjuvant ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna; Dobin, Alexander; Villanueva San Martín, Maite Upna; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Insights into c-di-GMP signaling and the PGA exopolysaccharide biological functions using Salmonella as a model organism 

      Echeverz Sarasúa, Maite Upna (2017)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Salmonella es un patógeno alimentario de gran relevancia clínica capaz de adherirse a superficies y formar comunidades bacterianas embebidas en una matriz que ellas mismas producen denominadas biofilms. Esta matriz ...
    • Killing niche competitors by remote-control bacteriophage induction 

      Selva, Laura; Viana, David; Regev Yochay, Gili; Trzcinski, Krzysztof; Corpa, Juan Manuel; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Penadés, José R. (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by ...
    • Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host 

      Echeverz Sarasúa, Maite Upna; García Martínez, Begoña Upna; Sabalza Baztán, Amaia; Valle Turrillas, Jaione Upna; Gabaldón Estevan, Juan Antonio; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the ...
    • Overlapping transcription and bacterial RNA removal 

      Lasa Uzcudun, Íñigo Upna; Villanueva San Martín, Maite Upna (National Academy of Sciences, 2014)   Artículo / Artikulua  OpenAccess
      The precise understanding of the biology of a living cell requires the identification and quantification of the molecular components necessary to sustain life. One such element is RNA. Two independent high-throughput ...
    • Post-transcriptional regulation mediated by 3’-UTRs in bacteria 

      Ruiz de los Mozos Aliaga, Igor Upna (2014)   Tesis doctoral / Doktoretza tesia  OpenAccess
      En organismos eucariotas, la presencia de elementos reguladores en las regiones 3’ no traducidas (3’-UTRs) del RNA mensajero (mRNA), que controlan su estabilidad y la eficiencia de su traducción, está ampliamente reconocida. ...
    • Protein A-mediated multicellular behavior in Staphylococcus aureus 

      Merino, Nekane; Toledo Arana, Alejandro Upna; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
      The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...
    • The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus 

      Caballero Sánchez, Carlos; Menéndez Gil, Pilar; Catalán Moreno, Arancha; Vergara Irigaray, Marta Upna; García Martínez, Begoña Upna; Segura, Víctor; Irurzun Domínguez, Naiara; Villanueva San Martín, Maite Upna; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna (Oxford University Press, 2018)   Artículo / Artikulua  OpenAccess
      RNA-binding proteins (RBPs) are essential to finetune gene expression. RBPs containing the coldshock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for ...
    • Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections 

      Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna; Merino, Nekane; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Ruiz de los Mozos Aliaga, Igor; Solano Goñi, Cristina Upna; Toledo Arana, Alejandro Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2009)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ...
    • RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria 

      Ferrer, María Desamparados; Quiles Puchalt, Nuria; Harwich, Michael D.; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Barbé, Jordi; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2011)   Artículo / Artikulua  OpenAccess
      Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ...
    • Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus 

      Cucarella, Carme; Tormo, M. Ángeles; Ubeda, Carles; Trotonda, M. Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ...
    • Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer 

      Maiques, Elisa; Ubeda, Carles; Tormo, María Ángeles; Ferrer, María Desamparados; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one or more of these islands ...
    • Salmonella biofilm development depends on the phosphorylation status of RcsB 

      Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
    • SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development 

      Tormo Más, María Ángeles; Martí, Miguel; Valle Turrillas, Jaione Upna; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      Staphylococcus epidermidis biofilm formation is associated with the production of the polysaccharide intercellular adhesin (PIA)--poly-N-acetylglucosamine polysaccharide (PNAG) by the products of the icaADBC operon. ...
    • SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus 

      Trotonda, María Pilar; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm formation ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna; García Martínez, Begoña Upna; Valle Turrillas, Jaione Upna; Rapún Araiz, Beatriz; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals 

      Taglialegna, Agustina Upna; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Matthews, Steve; Penadés, José R.; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (Public Library of Science, 2016)   Artículo / Artikulua  OpenAccess
      Major components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in ...
    • Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system 

      Toledo Arana, Alejandro Upna; Merino, Nekane; Vergara Irigaray, Marta Upna; Débarbouillé, Michel; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation capacity ...