• Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli 

      Moreno Bruna, Beatriz; Baroja Fernández, Edurne Upna; Muñoz Pérez, Francisco José; Bastarrica Berasategui, Ainara; Zandueta Criado, Aitor; Rodríguez López, Milagros; Lasa Uzcudun, Íñigo Upna; Akazawa, Takashi; Pozueta Romero, Javier Upna (National Academy of Sciences, 2001)   Artículo / Artikulua  OpenAccess
      An adenosine diphosphate sugar pyrophosphatase (ASPPase, EC 3.6.1.21) has been characterized by using Escherichia coli. This enzyme, whose activities in the cell are inversely correlated with the intracellular glycogen ...
    • Amyloid structures as biofilm matrix scaffolds 

      Taglialegna, Agustina Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2016)   Artículo / Artikulua  OpenAccess
      Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. ...
    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna; Toledo Arana, Alejandro Upna; Solano Goñi, Cristina Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Villanueva San Martín, Maite Upna; Bitarte, Nerea Upna; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Biofilm dispersion and quorum sensing 

      Solano Goñi, Cristina Upna; Echeverz Sarasúa, Maite Upna; Lasa Uzcudun, Íñigo Upna (Elsevier, 2014)   Artículo / Artikulua  OpenAccess
      Biofilm development and quorum sensing are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self produced extracellular matrix. ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna; Solano Goñi, Cristina Upna; Burgui Erice, Saioa Upna; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna; Valle Turrillas, Jaione Upna (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Toledo Arana, Alejandro Upna; Lasa Uzcudun, Íñigo Upna (Elsevier (Cell Press), 2013)   Artículo / Artikulua  OpenAccess
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate 

      Perez, A.; Canle, D.; Latasa Osta, Cristina Upna; Poza, M.; Beceiro, A.; del, Mar Tomas; Fernandez, A.; Mallo, S.; Perez, S.; Molina, F.; Villanueva, R.; Lasa Uzcudun, Íñigo Upna; Bou, Germán (American Society for Microbiology, 2007)   Artículo / Artikulua  OpenAccess
      Enterobacter cloacae is an emerging clinical pathogen that may be responsible for nosocomial infections. Management of these infections is often difficult, owing to the high frequency of strains that are resistant to ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Lasa Uzcudun, Íñigo Upna; Solano Goñi, Cristina Upna (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in enterobacter cloacae 

      Pérez, Astrid; Poza, Margarita; Aranda, Jesús; Latasa Osta, Cristina Upna; Medrano, Francisco Javier; Tomás, María; Romero, Antonio; Lasa Uzcudun, Íñigo Upna; Bou, Germán (American Society for Microbiology, december 2012, vol. 56, nº 12, p. 6256–6266, 2012)   Artículo / Artikulua  OpenAccess
      Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, ...
    • An effort to make sense of antisense transcription in bacteria 

      Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna; Gingeras, Thomas R. (Taylor & Francis, 2012)   Artículo / Artikulua  OpenAccess
      Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some ...
    • The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

      Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Arrizubieta Balerdi, María Jesús; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz Upna; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...
    • Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine 

      Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna; García Ona, Enrique Upna; Burgui Erice, Saioa Upna; Casares, Noelia; Hervás Stubbs, Sandra Upna; Lasarte, Juan José; Lasa Uzcudun, Íñigo Upna; Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Gil Puig, Carmen Upna (Public Library of Science, 2016)   Artículo / Artikulua  OpenAccess
      Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ...
    • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

      Valle Turrillas, Jaione Upna; Burgui Erice, Saioa Upna; Langheinrich, Denise; Gil Puig, Carmen Upna; Solano Goñi, Cristina Upna; Toledo Arana, Alejandro Upna; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo Upna (2015)   Artículo / Artikulua  OpenAccess
      Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
    • The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice 

      San Román Aberasturi, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Lasarte, Juan José; Grilló Dolset, María Jesús; Garrido, Victoria Upna; Muñoz Álvaro, Pilar María; Arribillaga, Laura; García Martínez, Begoña Upna; Andrés, Ximena de; Zabaleta, Virginia Upna; Mansilla, Cristina; Farrán Blanch, Inmaculada Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered with bacteria has not been assessed. Here, we investigated the adjuvant ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna; García Martínez, Begoña Upna; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna; Toledo Arana, Alejandro Upna; Dobin, Alexander; Villanueva San Martín, Maite Upna; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Insights into c-di-GMP signaling and the PGA exopolysaccharide biological functions using Salmonella as a model organism 

      Echeverz Sarasúa, Maite Upna (2017)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Salmonella es un patógeno alimentario de gran relevancia clínica capaz de adherirse a superficies y formar comunidades bacterianas embebidas en una matriz que ellas mismas producen denominadas biofilms. Esta matriz ...
    • Killing niche competitors by remote-control bacteriophage induction 

      Selva, Laura; Viana, David; Regev Yochay, Gili; Trzcinski, Krzysztof; Corpa, Juan Manuel; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Penadés, José R. (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by ...
    • Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host 

      Echeverz Sarasúa, Maite Upna; García Martínez, Begoña Upna; Sabalza Baztán, Amaia; Valle Turrillas, Jaione Upna; Gabaldón Estevan, Juan Antonio; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the ...