Now showing items 1-20 of 28

    • Anti-biofilm molecules targeting functional amyloids 

      Matilla Cuenca, Leticia Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing ...
    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna Orcid; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Solano Goñi, Cristina Upna Orcid; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Villanueva San Martín, Maite Upna Orcid; Bitarte, Nerea Upna; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Burgui Erice, Saioa Upna Orcid; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Elsevier (Cell Press), 2013)   Artículo / Artikulua  OpenAccess
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus 

      Arrizubieta Balerdi, María Jesús Upna; Toledo Arana, Alejandro Upna Orcid; Amorena Zabalza, Beatriz Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ...
    • Comparative and functional analysis of 3’ untranslated regions in Staphylococcus species 

      Menéndez Gil, Pilar (2020)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Una molécula de RNA mensajero (mRNA) está compuesta por una región codificante (CDS) flanqueada por dos regiones no traducidas (UTRs), la 5’UTR y la 3’UTR, respectivamente. En eucariotas, las 3’UTRs son elementos claves ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña Upna Orcid; Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • An effort to make sense of antisense transcription in bacteria 

      Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Gingeras, Thomas R. (Taylor & Francis, 2012)   Artículo / Artikulua  OpenAccess
      Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some ...
    • The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

      Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Arrizubieta Balerdi, María Jesús Upna; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz Upna; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...
    • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

      Valle Turrillas, Jaione Upna Orcid; Burgui Erice, Saioa Upna Orcid; Langheinrich, Denise; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo Upna Orcid (2015)   Artículo / Artikulua  OpenAccess
      Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
    • Fluorescent molecular beacons mimicking RNA secondary structures to study RNA chaperone activity 

      Menéndez Gil, Pilar; Caballero Sánchez, Carlos Upna; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid (Humana Press, 2020)   Capítulo de libro / Liburuen kapitulua  OpenAccess
      Molecular beacons (MBs) are oligonucleotide probes with a hairpin-like structure that are typically labelled at the 5′ and 3′ ends with a fluorophore and a quencher dye, respectively. The conformation of the MB acts as a ...
    • Functional analysis of the RNA chaperone CspA in Staphylococcus aureus 

      Caballero Sánchez, Carlos Upna (2018)   Tesis doctoral / Doktoretza tesia  OpenAccess
      En esta tesis se pone de manifiesto que las chaperonas de RNA, como CspA, pueden interactuar de manera específica con estructuras de RNA, que a su vez pueden ser reconocidas por otras RBPs. Esto contribuye a un mejor ...
    • Functional specificity and post-transcriptional regulation of the cold shock proteins in Staphylococcus aureus 

      Catalán Moreno, Arancha (2020)   Tesis doctoral / Doktoretza tesia
      En esta Tesis se han descifrado aspectos relevantes sobre las funciones de las proteínas CSPs de Staphylococcus aureus y su regulación, que pueden ser extrapoladas a otras bacterias. Específicamente, demostramos que sólo ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna Orcid; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna Orcid; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna Orcid (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genetic reductionist approach for studing the two-component signaling system in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna Orcid (2014)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Staphylococcus aureus es una bacteria ubicua capaz de colonizar una gran variedad de ambientes. En el hombre, S. aureus coloniza las fosas nasales, piel de las axilas, ingles, garganta o incluso el tracto intestinal. Se ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Dobin, Alexander; Villanueva San Martín, Maite Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • Noncontiguous operon is a genetic organization for coordinating bacterial gene expression 

      Sáenz Lahoya, S.; Bitarte, Nerea Upna; García, Beñat; Burgui Erice, Saioa Upna Orcid; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (National Academy of Sciences, 2019)   Artículo / Artikulua  OpenAccess
      Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ...
    • Post-transcriptional regulation mediated by 3’-UTRs in bacteria 

      Ruiz de los Mozos Aliaga, Igor Upna (2014)   Tesis doctoral / Doktoretza tesia  OpenAccess
      En organismos eucariotas, la presencia de elementos reguladores en las regiones 3’ no traducidas (3’-UTRs) del RNA mensajero (mRNA), que controlan su estabilidad y la eficiencia de su traducción, está ampliamente reconocida. ...
    • Protein A-mediated multicellular behavior in Staphylococcus aureus 

      Merino, Nekane Upna; Toledo Arana, Alejandro Upna Orcid; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
      The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...