Browsing by UPNA Author "Toledo Arana, Alejandro"
Now showing items 1-20 of 28
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Anti-biofilm molecules targeting functional amyloids
Matilla Cuenca, Leticia
; Toledo Arana, Alejandro ; Valle Turrillas, Jaione (MDPI, 2021)
Artículo / Artikulua 
The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing ... -
Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
Valle Turrillas, Jaione ; Latasa Osta, Cristina ; Gil Puig, Carmen ; Toledo Arana, Alejandro ; Solano Goñi, Cristina ; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)
Artículo / Artikulua
The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ... -
Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus
Ruiz de los Mozos Aliaga, Igor; Vergara Irigaray, Marta ; Segura, Víctor; Villanueva San Martín, Maite ; Bitarte, Nerea ; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro (Public Library of Science, 2013)
Artículo / Artikulua
The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ... -
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil Puig, Carmen ; Solano Goñi, Cristina ; Burgui Erice, Saioa ; Latasa Osta, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (American Society for Microbiology, 2014)
Artículo / Artikulua
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ... -
Biofilm switch and immune response determinants at early stages of infection
Valle Turrillas, Jaione ; Solano Goñi, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (Elsevier (Cell Press), 2013)
Artículo / Artikulua
Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ... -
Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus
Arrizubieta Balerdi, María Jesús; Toledo Arana, Alejandro ; Amorena Zabalza, Beatriz ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2004)
Artículo / Artikulua
Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ... -
Comparative and functional analysis of 3’ untranslated regions in Staphylococcus species
(2020) Tesis doctoral / Doktoretza tesia
Una molécula de RNA mensajero (mRNA) está compuesta por una región codificante (CDS) flanqueada por dos regiones no traducidas (UTRs), la 5’UTR y la 3’UTR, respectivamente. En eucariotas, las 3’UTRs son elementos claves ... -
Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose
Zorraquino Salvo, Violeta; García Martínez, Begoña ; Latasa Osta, Cristina ; Echeverz Sarasúa, Maite ; Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina (American Society for Microbiology, 2013)
Artículo / Artikulua
Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ... -
An effort to make sense of antisense transcription in bacteria
Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro ; Gingeras, Thomas R. (Taylor & Francis, 2012)
Artículo / Artikulua
Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some ... -
The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation
Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Arrizubieta Balerdi, María Jesús ; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz ; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2001)
Artículo / Artikulua
The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ... -
Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling
Valle Turrillas, Jaione ; Burgui Erice, Saioa ; Langheinrich, Denise; Gil Puig, Carmen ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo (2015)
Artículo / Artikulua
Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ... -
Fluorescent molecular beacons mimicking RNA secondary structures to study RNA chaperone activity
Menéndez Gil, Pilar; Caballero Sánchez, Carlos; Solano Goñi, Cristina ; Toledo Arana, Alejandro (Humana Press, 2020)
Capítulo de libro / Liburuen kapitulua
Molecular beacons (MBs) are oligonucleotide probes with a hairpin-like structure that are typically labelled at the 5′ and 3′ ends with a fluorophore and a quencher dye, respectively. The conformation of the MB acts as a ... -
Functional analysis of the RNA chaperone CspA in Staphylococcus aureus
Caballero Sánchez, Carlos (2018)
Tesis doctoral / Doktoretza tesia
En esta tesis se pone de manifiesto que las chaperonas de RNA, como CspA, pueden interactuar de manera específica con estructuras de RNA, que a su vez pueden ser reconocidas por otras RBPs. Esto contribuye a un mejor ... -
Functional specificity and post-transcriptional regulation of the cold shock proteins in Staphylococcus aureus
(2020) Tesis doctoral / Doktoretza tesia
En esta Tesis se han descifrado aspectos relevantes sobre las funciones de las proteínas CSPs de Staphylococcus aureus y su regulación, que pueden ser extrapoladas a otras bacterias. Específicamente, demostramos que sólo ... -
Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella
Solano Goñi, Cristina ; García Martínez, Begoña ; Latasa Osta, Cristina ; Toledo Arana, Alejandro ; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione ; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo (National Academy of Sciences, 2009)
Artículo / Artikulua
Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ... -
Genetic reductionist approach for studing the two-component signaling system in Staphylococcus aureus
Villanueva San Martín, Maite (2014)
Tesis doctoral / Doktoretza tesia
Staphylococcus aureus es una bacteria ubicua capaz de colonizar una gran variedad de ambientes. En el hombre, S. aureus coloniza las fosas nasales, piel de las axilas, ingles, garganta o incluso el tracto intestinal. Se ... -
Genome-wide antisense transcription drives mRNA processing in bacteria
Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro ; Dobin, Alexander; Villanueva San Martín, Maite ; Ruiz de los Mozos Aliaga, Igor ; Vergara Irigaray, Marta ; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Gingeras, Thomas R. (National Academy of Sciences, 2011)
Artículo / Artikulua
RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ... -
Noncontiguous operon is a genetic organization for coordinating bacterial gene expression
Sáenz Lahoya, S.; Bitarte, Nerea; García, Beñat; Burgui Erice, Saioa ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (National Academy of Sciences, 2019)
Artículo / Artikulua
Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ... -
Post-transcriptional regulation mediated by 3’-UTRs in bacteria
Ruiz de los Mozos Aliaga, Igor (2014)
Tesis doctoral / Doktoretza tesia
En organismos eucariotas, la presencia de elementos reguladores en las regiones 3’ no traducidas (3’-UTRs) del RNA mensajero (mRNA), que controlan su estabilidad y la eficiencia de su traducción, está ampliamente reconocida. ... -
Protein A-mediated multicellular behavior in Staphylococcus aureus
Merino, Nekane; Toledo Arana, Alejandro ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2008)
Artículo / Artikulua
The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...
