Listar por autor UPNA "García Castillo, Jesús María"
Mostrando ítems 1-7 de 7
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4-Hydroxy-4-methylpent-1-en-3-one
[22082-43-5] C6H10O2 (MW 114.14) InChI = 1S/C6H10O2/c1-4-5(7)6(2,3)8/h4,8H,1H2,2-3H3 InChIKey = CANVUQXZGKVFSR-UHFFFAOYSA-N (electrophilic alkene used as an equivalent of acrylic acid and derived esters in Diels–Alder and ... -
Asymmetric assembly of all‐carbon tertiary/quaternary nonadjacent stereocenters through organocatalytic conjugate addition of α‐cyanoacetates to a methacrylate equivalent
An efficient, highly diastereo- and enantioselective assembly of acyclic carbonyl fragments possessing nonadjacent all-carbon tertiary/quaternary stereoarrays is reported based on a Brønsted base catalyzed Michael ... -
Asymmetric propionate aldol reactions of a chiral lithium enolate accessible from direct enolization with n-butyllithium
The presented lithium enolate-based methodology is suitable for access to propionate syn-aldol motifs with high levels of stereocontrol. The reactive lithium enolate species is generated by direct treatment of a camphor-based ... -
Development of an α′-hydroxy enone for the aminocatalytic asymmetric formal conjugate addition of aldehydes to acrylates, vinyl ketones and acrolein
(Royal Society of Chemistry, 2023) Artículo / ArtikuluaAminocatalytic asymmetric conjugate addition of aldehydes to Michael acceptors is a well established C-C bond forming methodology. However, various acrylic-type acceptors, including acrylic acid derivatives and acrolein, ... -
Enantioselective addition of alkynyl ketones to nitroolefins assisted by Brønsted base/H-bonding catalysis
Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts ... -
Organocatalytic Michael addition of unactivated a-branched nitroalkanes to afford optically active tertiary nitrocompounds
The direct, asymmetric conjugate addition of unactivated ¿-branched nitroalkanes is developed based on the combined use of chiral amine/ureidoaminal bifunctional catalysts and a tunable acrylate template to provide tertiary ... -
α-Hydroxy ketones as masked ester donors in Brønsted base catalyzed conjugate additions to nitroalkenes
The catalyst-controlled enantioselective direct addition reaction of enolizable esters and related carboxylic acid derivatives to p electrophiles remains a difficult synthetic transformation. In this study, the suitability ...