Browsing by UPNA Author "Latasa Osta, Cristina"
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Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
Valle Turrillas, Jaione
; Latasa Osta, Cristina ; Gil Puig, Carmen ; Toledo Arana, Alejandro ; Solano Goñi, Cristina ; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)
Artículo / Artikulua 
The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ... -
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil Puig, Carmen ; Solano Goñi, Cristina ; Burgui Erice, Saioa ; Latasa Osta, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (American Society for Microbiology, 2014)
Artículo / Artikulua
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ... -
Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate
Pérez, Astrid; Canle, Delia; Latasa Osta, Cristina; Poza, Margarita; Beceiro, Alejandro; Tomás, María del Mar; Fernández, Ana; Mallo, Susana; Pérez, Sonia; Molina, Francisca; Villanueva González, Rosa; Lasa Uzcudun, Íñigo ; Bou, Germán (American Society for Microbiology, 2007)
Artículo / Artikulua
Enterobacter cloacae is an emerging clinical pathogen that may be responsible for nosocomial infections. Management of these infections is often difficult, owing to the high frequency of strains that are resistant to ... -
Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose
Zorraquino Salvo, Violeta; García Martínez, Begoña ; Latasa Osta, Cristina ; Echeverz Sarasúa, Maite ; Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina (American Society for Microbiology, 2013)
Artículo / Artikulua
Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ... -
A DIVA vaccine strain lacking RpoS and the secondary messenger c-di-GMP for protection against salmonellosis in pigs
Gil Puig, Carmen ; Latasa Osta, Cristina ; García Ona, Enrique ; Lázaro, Isidro; Labairu, Javier; Echeverz Sarasúa, Maite ; Burgui Erice, Saioa ; García Martínez, Begoña ; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina (BioMed Central, 2020)
Artículo / Artikulua
Salmonellosis is the second most common food-borne zoonosis in the European Union, with pigs being a major reservoir of this pathogen. Salmonella control in pig production requires multiple measures amongst which vaccination ... -
Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in enterobacter cloacae
Pérez, Astrid; Poza, Margarita; Aranda, Jesús; Latasa Osta, Cristina; Medrano, Francisco Javier; Tomás, María del Mar; Romero, Antonio; Lasa Uzcudun, Íñigo ; Bou, Germán (American Society for Microbiology, 2012)
Artículo / Artikulua
Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, ... -
Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine
Latasa Osta, Cristina; Echeverz Sarasúa, Maite ; García Ona, Enrique ; Burgui Erice, Saioa ; Casares, Noelia; Hervás Stubbs, Sandra ; Lasarte, Juan José; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina ; García Martínez, Begoña ; Gil Puig, Carmen (Public Library of Science, 2016)
Artículo / Artikulua
Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ... -
Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella
Solano Goñi, Cristina ; García Martínez, Begoña ; Latasa Osta, Cristina ; Toledo Arana, Alejandro ; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione ; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo (National Academy of Sciences, 2009)
Artículo / Artikulua
Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ... -
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
Prieto Mariscal, Juana María; Rapún Araiz, Beatriz ; Gil Puig, Carmen ; Penadés, José R.; Lasa Uzcudun, Íñigo ; Latasa Osta, Cristina (Nature Research, 2020)
Artículo / Artikulua
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS) that determines bacterial ... -
Novel strategies for treating biofilm and MRSA associated infections
(2021) Tesis doctoral / Doktoretza tesia
En esta tesis hemos trabajado en dos estrategias, un cribado fenotípico y otro frente a una diana específica, que podrían ayudar a ampliar las alternativas terapéuticas frente a S. aureus. En el primer capítulo, nos hemos ... -
Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica
Medina-Ruiz, Laura; Campoy Sánchez, Susana; Latasa Osta, Cristina; Cardenas, Paula; Alonso, Juan Carlos; Barbé, Jordi (American Society for Microbiology, 2010)
Artículo / Artikulua
Transcription of the Salmonella enterica recA gene is negatively controlled by the LexA protein, the repressor of the SOS response. The introduction of a mutation (recAo6869) in the LexA binding site, in the promoter region ... -
Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections
Vergara Irigaray, Marta; Valle Turrillas, Jaione ; Merino, Nekane ; Latasa Osta, Cristina ; García Martínez, Begoña ; Ruiz de los Mozos Aliaga, Igor ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2009)
Artículo / Artikulua
Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ... -
Salmonella biofilm development depends on the phosphorylation status of RcsB
Latasa Osta, Cristina; García Martínez, Begoña ; Echeverz Sarasúa, Maite ; Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina ; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2012)
Artículo / Artikulua
The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
