Browsing by UPNA Author "Lázcoz, Paula"
Now showing items 1-6 of 6
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Analysis of stemness gene expression and CD133 abnormal methylation in neuroblastoma cell lines
Schiapparelli, Paula; Enguita Germán, Mónica; Balbuena, Jana; Rey, Juan A.; Lázcoz, Paula
; Castresana, Javier S. (Spandidos Publications, 2010)
Artículo / Artikulua 
Neuroblastoma is the most common extracranial solid tumor in children, accounting for up to 10% of all childhood malignancies. Cellular heterogeneity is a hallmark of this embryonal cancer, as distinct neural crest lineages ... -
Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment
Celay Leoz, Ion; Blanco Luquin, Idoia; Lázcoz, Paula ; Rotinen Díaz, Mirja Sofia 
; Castresana, Javier S.; Encío Martínez, Ignacio (Public Library of Science, 2013)
Artículo / Artikulua
To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ... -
Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR
Lorente, Aiala; Mueller, Wolf; Urdangarín, Edurne; Lázcoz, Paula; Deimling, Andreas von; Sáez Castresana, Javier (BioMed Central, 2008)
Artículo / Artikulua
Background: We present two melting curve analysis (MCA)-based semiquantitative real time PCR techniques to detect the promoter methylation status of genes. The first, MCA-MSP, follows the same principle as standard MSP ... -
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma
Lázcoz, Paula; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio ; Sáez Castresana, Javier (BioMed Central, 2006)
Artículo / Artikulua
Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ... -
In vitro assessment of the role of p53 on chemotherapy treatments in neuroblastoma cell lines
Blanco Luquin, Idoia; Lázcoz, Paula; Celay Leoz, Ion ; Castresana, Javier S.; Encío Martínez, Ignacio (MDPI, 2021)
Artículo / Artikulua
Neuroblastoma is the most frequent malignant extracranial solid tumor of infancy. The overall objective of this work consists of determining the presence of alterations in the p53/MDM2 /p14ARF signaling pathway in neuroblastoma ... -
Promoter methylation of RASSF1A associates to adult secondary glioblastomas and pediatric glioblastomas
Muñoz, Jorge; Inda, María del Mar; Lázcoz, Paula; Zazpe, Idoya; Fan, Xing; Alfaro, Jorge; Tuñón Álvarez, Teresa; Rey, Juan A.; Castresana, Javier S. (Hindawi / Wiley, 2012)
Artículo / Artikulua
While allelic losses and mutations of tumor suppressor genes implicated in the etiology of astrocytoma have been widely assessed, the role of epigenetics is still a matter of study. We analyzed the frequency of promoter ...
