Browsing by UPNA Author "Gil Puig, Carmen"
Now showing items 1-13 of 13
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Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids
Matilla Cuenca, Leticia
; Gil Puig, Carmen ; Cuesta Ferre, Sergio; Rapún Araiz, Beatriz ; Mira, Alex; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione ; Ziemité, Miglé (Nature Research, 2020)
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The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ... -
Bacterial biofilm functionalization through Bap amyloid engineering
Matilla Cuenca, Leticia ; Taglialegna, Agustina ; Gil Puig, Carmen ; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione (Springer Nature, 2022)
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Biofilm engineering has emerged as a controllable way to fabricate living structures with programmable functionalities. The amyloidogenic proteins comprising the biofilms can be engineered to create self-assembling ... -
Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
Valle Turrillas, Jaione ; Latasa Osta, Cristina ; Gil Puig, Carmen ; Toledo Arana, Alejandro ; Solano Goñi, Cristina ; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)
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The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ... -
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil Puig, Carmen ; Solano Goñi, Cristina ; Burgui Erice, Saioa ; Latasa Osta, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (American Society for Microbiology, 2014)
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The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ... -
Characterization of nontypable haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection
Garmendia García, Juncal; Viadas Martínez, Cristina; Calatayud, Laura; Mell, Joshua Chang; Martí Lliteras, Pau; Euba, Begoña; Llobet, Enrique; Gil Puig, Carmen ; Bengoechea Alonso, José Antonio; Redfield, Rosemary J.; Liñares, Josefina (Public Library of Science, 2014)
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Nontypable Haemophilus influenzae (NTHi) has emerged as an important opportunistic pathogen causing infection in adults suffering obstructive lung diseases. Existing evidence associates chronic infection by NTHi to the ... -
A DIVA vaccine strain lacking RpoS and the secondary messenger c-di-GMP for protection against salmonellosis in pigs
Gil Puig, Carmen ; Latasa Osta, Cristina ; García Ona, Enrique ; Lázaro, Isidro; Labairu, Javier; Echeverz Sarasúa, Maite ; Burgui Erice, Saioa ; García Martínez, Begoña ; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina (BioMed Central, 2020)
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Salmonellosis is the second most common food-borne zoonosis in the European Union, with pigs being a major reservoir of this pathogen. Salmonella control in pig production requires multiple measures amongst which vaccination ... -
Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine
Latasa Osta, Cristina; Echeverz Sarasúa, Maite ; García Ona, Enrique ; Burgui Erice, Saioa ; Casares, Noelia; Hervás Stubbs, Sandra ; Lasarte, Juan José; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina ; García Martínez, Begoña ; Gil Puig, Carmen (Public Library of Science, 2016)
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Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ... -
Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling
Valle Turrillas, Jaione ; Burgui Erice, Saioa ; Langheinrich, Denise; Gil Puig, Carmen ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo (2015)
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Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ... -
Increased biofilm formation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections
Gil Puig, Carmen ; Domenech, Arnau; Garmendia García, Juncal; Langereis, Jeroen D.; Mayer, Pascal; Calatayud, Laura; Liñares, Josefina; Ardanuy, Carmen; Martí, Sara (American Society for Microbiology, 2014)
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Biofilm formation by nontypeable (NT) Haemophilus influenzae remains a controversial topic. Nevertheless, biofilm-like structures have been observed in the middle-ear mucosa of experimental chinchilla models of otitis media ... -
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
Prieto Mariscal, Juana María; Rapún Araiz, Beatriz ; Gil Puig, Carmen ; Penadés, José R.; Lasa Uzcudun, Íñigo ; Latasa Osta, Cristina (Nature Research, 2020)
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Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS) that determines bacterial ... -
Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis
Morey, Pau; Viadas Martínez, Cristina; Euba, Begoña; Hood, Derek W.; Barberán, Montserrat; Gil Puig, Carmen ; Grilló Dolset, María Jesús; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (American Society for Microbiology, 2013)
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Nontypeable Haemophilus influenzae (NTHi) is a frequent commensal of the human nasopharynx that causes opportunistic infection in immunocompromised individuals. Existing evidence associates lipooligosaccharide (LOS) with ... -
A systematic evaluation of the two-component systems network reveals that ArlRS is a key regulator of catheter colonization by Staphylococcus aureus
Burgui Erice, Saioa ; Gil Puig, Carmen ; Solano Goñi, Cristina ; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (Frontiers Media, 2018)
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Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the ... -
Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus
Rapún Araiz, Beatriz ; Haag, Andreas F.; Gil Puig, Carmen ; Dorado Morales, Pedro ; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2020)
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In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different ...
