Listar por autor UPNA "Mendaza Lainez, Saioa"

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    • Absence of nuclear p16 is a diagnostic and independent prognostic biomarker in squamous cell carcinoma of the cervix 

      Mendaza Lainez, Saioa Upna; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Zudaire, Tamara; Guarch, Rosa; Guerrero Setas, David (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our ...

    • ADAM12 is a potential therapeutic target regulated by hypomethylation in triple-negative breast cancer 

      Mendaza Lainez, Saioa Upna; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Córdoba Iturriagagoitia, Alicia; Ruiz de Azúa, Yerani (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and currently lacks any effective targeted therapy. Since epigenetic alterations are a common event in TNBC, DNA methylation profiling can ...

    • Approaching the epigenome of triple negative breast cancer to identify new biomarkers 

      Mendaza Lainez, Saioa Upna (2020)   Tesis doctoral / Doktoretza tesia  OpenAccess
      El cáncer de mama (CM) es la neoplasia más frecuente en todo el mundo y la primera causa de muerte por cáncer en mujeres. El cáncer de mama triple negativo (CMTN) representa el 10-20% de todos los CM diagnosticados y es ...

    • CDH22 hypermethylation is an independent prognostic biomarker in breast cancer 

      Martín Sánchez, Esperanza; Mendaza Lainez, Saioa Upna; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Blanco Luquin, Idoia; Cruz, Susana de la; Aramendia, Ana; Guerrero Setas, David (BioMed Central, 2017)   Artículo / Artikulua  OpenAccess
      Background: Cadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in ...

    • CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer 

      Martín Sánchez, Esperanza; Mendaza Lainez, Saioa Upna; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Blanco Luquin, Idoia; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Pérez Janices, Noemi; Escors Murugarren, David; Megías, Diego (Impact Journals, 2017)   Artículo / Artikulua  OpenAccess
      The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation ...

    • A DNA methylation-based gene signature can predict triple-negative breast cancer diagnosis 

      Mendaza Lainez, Saioa Upna; Guerrero Setas, David; Monreal Santesteban, Iñaki; Ulazia Garmendia, Ane; Córdoba Iturriagagoitia, Alicia; Cruz, Susana de la; Martín Sánchez, Esperanza (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Triple-negative breast cancer (TNBC) is the most aggressive breast cancer (BC) subtype and lacks targeted treatment. It is diagnosed by the absence of immunohistochemical expression of several biomarkers, but this method ...
      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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