Listar por autor "Santamaría, Enrique"
Mostrando ítems 21-40 de 57
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The human gastric juice: a promising source for gastric cancer biomarkers
Felípez, Nayra; Montori, Sheyla; Mendizuri, Naroa; Llach, Joan; Delgado, Pedro G.; Moreira, Leticia; Santamaría, Enrique; Fernández Irigoyen, Joaquín
; Albéniz Arbizu, Eduardo (MDPI, 2023)
Artículo / Artikulua 
Gastric cancer (GC) is a major public health problem worldwide, with high mortality rates due to late diagnosis and limited treatment options. Biomarker research is essential to improve the early detection of GC. Technological ... -
Improvement of cognitive function in wild-type and Alzheimer's disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells
Casares, Noelia; Alfaro Larraya, María; Cuadrado-Tejedor, Mar; Lasarte-Cía, Aritz; Navarro Negredo, Flor; Vivas, Isabel; Espelosín, María; Cartas-Cejudo, Paz; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; García-Osta, Ana; Lasarte, Juan José (Frontiers Media, 2023)
Artículo / Artikulua
A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing ... -
Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
Andrés Benito, Pol; Povedano, Mónica; Domínguez Rubio, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020)
Artículo / Artikulua
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ... -
Influence of short-term training on functional capacity and (anti-)inflammatory immune signalling in acute hospitalization
Ramírez Vélez, Robinson ; Martínez Velilla, Nicolás ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Izquierdo Redín, Mikel ; Palomino Echeverría, Sara (Wiley, 2020)
Artículo / Artikulua
To investigate the infuence of exercise on inflammatory signalling, it was performed cytokine array profiling in human serum to identify inflammatory cytokines produced after a 3 day in-hospital intervention including ... -
Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model
Passman, Adam M.; Strauss, Robyn P.; McSpadden, Sarah B.; Finch-Edmondson, Megan; Andrewartha, Neil; Woo, Ken H.; Diepeveen, Luke A.; Zhao, Weihao; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Medina-Ruiz, Laura; Szpakowska, Martyna; Chevigné, Andy; Park, Hyerin; Carlessi, Rodrigo; Tirnitz-Parker, Janina; Blanco, José R.; London, Roslyn; Callus, Bernard A.; Elsegood, Caryn L.; Baker, Murray V.; Martínez, Alfredo; Yeoh, George C.T.; Ochoa-Callejero, Laura (MDPI, 2021)
Artículo / Artikulua
Maraviroc (MVC), a CCR5 antagonist, reduces liver fibrosis, injury and tumour burden in mice fed a hepatocarcinogenic diet, suggesting it has potential as a cancer therapeutic. We investigated the effect of MVC on liver ... -
Mass spectrometry-based proteomic profiling of thrombotic material obtained by endovascular thrombectomy in patients with ischemic stroke
Muñoz, Roberto; Santamaría, Enrique; Rubio, Idoya; Ausín, Karina; Labarga, Alberto (MDPI, 2018)
Artículo / Artikulua
Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein ... -
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Echaide Górriz, Míriam; Blanco, Ester; Chocarro, Luisa ; Toro, María de; Escors Murugarren, David; Fernández Irigoyen, Joaquín ; Kochan, Grazyna; Santamaría, Enrique (Frontiers Media, 2022)
Artículo / Artikulua
One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ... -
Metschnikowia pulcherrima as an efficient biocontrol agent of Botrytis cinerea infection in apples: unraveling protection mechanisms through yeast proteomics
Fernández San Millán, Alicia ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Larraya Reta, Luis María ; Farrán Blanch, Inmaculada; Veramendi Charola, Jon (Elsevier, 2023)
Artículo / Artikulua
The results obtained in this study show that the Mp-30 strain of Metschnikowia pulcherrima is able to completely prevent Botrytis cinerea infection in apples, which is a major postharvest disease of fruits throughout the ... -
Mitochondrial oxidative stress induces cardiac fibrosis in obese rats through modulation of transthyretin
Martínez Martínez, Ernesto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Nieto, María Luisa; Bravo San Pedro, José Manuel; Cachofeiro, Victoria (MDPI, 2022)
Artículo / Artikulua
A proteomic approach was used to characterize potential mediators involved in the improvement in cardiac fibrosis observed with the administration of the mitochondrial antioxidant MitoQ in obese rats. Male Wistar rats were ... -
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
Colomé, Núria; Abian, Joaquín; Aloria, Kerman; Arizmendi, Jesús M.; Barceló-Batllori, Silvia; Braga-Lagache, Sophie; Burlet-Schiltz, Odile; Carrascal, Montse; Casal, Ignacio J.; Chicano-Gálvez, Eduard; Chiva, Cristina; Clemente, Luis F.; Elortza, Félix; Estanyol, Josep M.; Fernández Irigoyen, Joaquín ; Fernández-Puente, Patricia; Fidalgo, María J.; Froment, Carine; Fuentes, Manuel; Fuentes-Almagro, Carlos; Gay, Marina; Hainard, Alexandre; Heller, Manfred; Hernández, María Luisa; Ibarrola, Nieves; Iloro, Ibon; Kieselbach, Thomas; Lario, Antonio; Locard-Paulet, Marie; Marina-Ramírez, Anabel; Martín, Luna; Morato-López, Esperanza; Muñoz, Javier; Navajas, Rosana; Odena, Antonia M.; Odriozola, Leticia; Oliveira, Eliandre de; Paradela, Alberto; Pasquarello, Carla; Rios, Vivian de los; Ruiz-Romero, Cristina; Sabidó, Eduard; Sánchez del Pino, Manuel; Sancho, Jaime; Santamaría, Enrique; Schaeffer-Reiss, Christine; Schneider, Justine; Torre, Carolina de la; Valero, Luz M.; Vilaseca, Marta; Wu, Shuai; Wu, Linfeng; Ximénez de Embún, Pilar; Canals, Francesc; Corrales, Fernando J.; ProteoRed-ISCIII; EuPA (Elsevier, 2022)
Artículo / Artikulua
Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that make ... -
Network-driven proteogenomics unveils an aging-related imbalance in the olfactory IκBα-NFκB p65 complex functionality in Tg2576 Alzheimer’s disease mouse model
Palomino Alonso, Maialen; Lachén Montes, Mercedes ; González Morales, Andrea ; Ausín, Karina; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2017)
Artículo / Artikulua
Olfaction is often deregulated in Alzheimer’s disease (AD) patients, and is also impaired in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little ... -
Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
Iridoy Zulet, Marina; Zubiri, Irene; Zelaya Huerta, María Victoria ; Martínez, Leire; Ausín, Karina; Lachén Montes, Mercedes ; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Jericó Pascual, Ivonne (MDPI, 2019)
Artículo / Artikulua
(1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common and differential mechanisms leading ... -
New in vivo approach to broaden the thioredoxin family interactome in chloroplasts
Ancín Rípodas, María ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Larraya Reta, Luis María ; Fernández San Millán, Alicia ; Veramendi Charola, Jon ; Farrán Blanch, Inmaculada (MDPI, 2022)
Artículo / Artikulua
Post-translational redox modifications provide an important mechanism for the control of major cellular processes. Thioredoxins (Trxs), which are key actors in this regulatory mechanism, are ubiquitous proteins that catalyse ... -
Olfaction and neurodegeneration: olfactory proteotyping across proteinopathies
Lachén Montes, Mercedes (2019)
Tesis doctoral / Doktoretza tesia
La disfunción olfatoria es un síntoma temprano y común en diversas enfermedades neurodegenerativas (ENs). Según el grado de disfunción olfatoria que presentan, existen ENs con disfunción olfatoria pronunciada, como la ... -
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression
Lachén Montes, Mercedes ; González Morales, Andrea ; Zelaya Huerta, María Victoria ; Pérez Valderrama, Estela; Ausín, Karina; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Springer Nature, 2017)
Artículo / Artikulua
Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- ... -
Olfactory bulb proteomics reveals widespread proteostatic disturbances in mixed dementia and guides for potential serum biomarkers to discriminate alzheimer disease and mixed dementia phenotypes
Lachén Montes, Mercedes ; Íñigo-Marco, Ignacio; Cartas-Cejudo, Paz; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2021)
Artículo / Artikulua
The most common form of mixed dementia (MixD) is constituted by abnormal protein deposits associated with Alzheimer's disease (AD) that coexist with vascular disease. Although olfactory dysfunction is considered a clinical ... -
Olfactory characterization and training in older adults: protocol study
Zambom Ferraresi, Fabíola ; Zambom Ferraresi, Fabrício ; Fernández Irigoyen, Joaquín ; Lachén Montes, Mercedes ; Cartas-Cejudo, Paz; Lasarte, Juan José; Casares, Noelia; Fernández, Secundino; Cedeño Veloz, Bernardo Abel; Maraví-Aznar, Enrique; Uzcanga-Lacabe, María Itziar; Galbete Jiménez, Arkaitz ; Santamaría, Enrique; Martínez Velilla, Nicolás (Frontiers Media, 2021)
Artículo / Artikulua
The aim of this article is to present the research protocol for a prospective cohort study that will assess the olfactory function and the effect of an intervention based on olfactory training in healthy very old adults ... -
Omics approaches in pancreatic adenocarcinoma
González Borja, Iranzu; Viúdez, Antonio; Goñi Irigoyen, Saioa ; Santamaría, Enrique; Carrasco García, Estefanía; Pérez Sanz, Jairo; Hernández García, Irene (MDPI, 2019)
Artículo / Artikulua
Pancreatic ductal adenocarcinoma, which represents 80% of pancreatic cancers, is mainly diagnosed when treatment with curative intent is not possible. Consequently, the overall five-year survival rate is extremely dismal—around ... -
Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy
González Morales, Andrea ; Zabaleta, Aintzane; García Moure, Marc; Alonso Roldán, Marta ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Elsevier, 2018)
Artículo / Artikulua
Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection ... -
Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies
Lachén Montes, Mercedes ; Zelaya Huerta, María Victoria ; Segura, Víctor; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Impact Journals, 2017)
Artículo / Artikulua
Alzheimer´s disease (AD) is characterized by progressive dementia, initially presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central structure of the olfactory pathway, we lack a complete ...
