• Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Dobin, Alexander; Villanueva San Martín, Maite Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...
    • The impact of two-component sensorial network in staphylococcal speciation 

      Rapún Araiz, Beatriz Upna Orcid; Haag, Andreas F.; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Elsevier, 2020)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to their environments. Free-living bacteria usually contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. ...
    • Insights into c-di-GMP signaling and the PGA exopolysaccharide biological functions using Salmonella as a model organism 

      Echeverz Sarasúa, Maite Upna Orcid (2017)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Salmonella es un patógeno alimentario de gran relevancia clínica capaz de adherirse a superficies y formar comunidades bacterianas embebidas en una matriz que ellas mismas producen denominadas biofilms. Esta matriz ...
    • Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host 

      Echeverz Sarasúa, Maite Upna Orcid; García Martínez, Begoña Upna Orcid; Sabalza Baztán, Amaia Upna; Valle Turrillas, Jaione Upna Orcid; Gabaldón Estevan, Juan Antonio; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Public Library of Science, 2017)   Artículo / Artikulua  OpenAccess
      Many bacteria build biofilm matrices using a conserved exopolysaccharide named PGA or PNAG (poly-β-1,6-N-acetyl-D-glucosamine). Interestingly, while E. coli and other members of the family Enterobacteriaceae encode the ...
    • Noncontiguous operon is a genetic organization for coordinating bacterial gene expression 

      Sáenz Lahoya, S.; Bitarte, Nerea Upna; García, Beñat; Burgui Erice, Saioa Upna Orcid; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (National Academy of Sciences, 2019)   Artículo / Artikulua  OpenAccess
      Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ...
    • Polymicrobial infections: do bacteria behave differently depending on their neighbours? 

      Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (Taylor & Francis, 2018)   Otros / Bestelakoak  OpenAccess
      Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected ...
    • Protein A-mediated multicellular behavior in Staphylococcus aureus 

      Merino, Nekane Upna; Toledo Arana, Alejandro Upna Orcid; Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
      The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ...
    • Regulation of gene expression by non-phosphorylated response regulators 

      Gómez Arrebola, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo (Institut d'Estudis Catalans, 2021)   Artículo / Artikulua  OpenAccess
      Two-component systems (TCSs) are a prominent sensory system in bacteria. A prototypical TCS comprises a membrane-bound sensor histidine kinase (HK) responsible for sensing the signal and a cytoplasmic response regulator ...
    • The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus 

      Caballero Sánchez, Carlos Upna; Menéndez Gil, Pilar; Catalán Moreno, Arancha; Vergara Irigaray, Marta Upna; García Martínez, Begoña Upna Orcid; Segura, Víctor; Irurzun Domínguez, Naiara; Villanueva San Martín, Maite Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid (Oxford University Press, 2018)   Artículo / Artikulua  OpenAccess
      RNA-binding proteins (RBPs) are essential to finetune gene expression. RBPs containing the coldshock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for ...
    • Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections 

      Vergara Irigaray, Marta Upna; Valle Turrillas, Jaione Upna Orcid; Merino, Nekane Upna; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2009)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ...
    • Salmonella biofilm development depends on the phosphorylation status of RcsB 

      Latasa Osta, Cristina Upna; García Martínez, Begoña Upna Orcid; Echeverz Sarasúa, Maite Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna Orcid; García Martínez, Begoña Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Rapún Araiz, Beatriz Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna Orcid; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system 

      Gómez Arrebola, Carmen Upna Orcid; Hernández, Sara B.; Culp, Elizabeth J.; Wright, Gerard D.; Solano Goñi, Cristina Upna Orcid; Cava, Felipe; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2023)   Artículo / Artikulua  OpenAccess
      The overuse of antibiotics in humans and livestock has driven the emergence and spread of antimicrobial resistance and has therefore prompted research on the discovery of novel antibiotics. Complestatin (Cm) and corbomycin ...
    • A systematic evaluation of the two-component systems network reveals that ArlRS is a key regulator of catheter colonization by Staphylococcus aureus 

      Burgui Erice, Saioa Upna Orcid; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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