Listar por autor "Ferrer, Isidro"
Mostrando ítems 1-11 de 11
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Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2020) Artículo / ArtikuluaAmyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ... -
Deregulated transcription and proteostasis in adult mapt knockout mouse
Andrés Benito, Pol; Flores, África; Busquet-Areny, Sara; Carmona, Margarita; Ausín, Karina; Cartas Cejudo, Paz; Lachén Montes, Mercedes ; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2023) Artículo / ArtikuluaTranscriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ... -
Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer's disease
Ferrer, Isidro; Andrés Benito, Pol; Ausín, Karina; Pamplona, Reinald; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Wiley, 2021) Artículo / ArtikuluaTau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ... -
Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease
Lachén Montes, Mercedes ; González Morales, Andrea ; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria ; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Frontiers Media, 2019) Artículo / ArtikuluaThe olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ... -
Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
Ferrer, Isidro; Andrés Benito, Pol; Zelaya Huerta, María Victoria ; Erro Aguirre, María Elena; Carmona, Margarita; Ausín, Karina; Lachén Montes, Mercedes ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del (Springer, 2020) Artículo / ArtikuluaGlobular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, ... -
Host tau genotype specifically designs and regulates tau seeding and spreading and host tau transformation following intrahippocampal injection of identical tau AD inoculum
Andrés Benito, Pol; Carmona, Margarita; Jordán, Mónica; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del; Ferrer, Isidro (MDPI, 2022) Artículo / ArtikuluaSeveral studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. ... -
Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
Andrés Benito, Pol; Povedano, Mónica; Domínguez Rubio, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020) Artículo / ArtikuluaSporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ... -
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression
Lachén Montes, Mercedes ; González Morales, Andrea ; Zelaya Huerta, María Victoria ; Pérez Valderrama, Estela; Ausín, Karina; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Springer Nature, 2017) Artículo / ArtikuluaOlfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- ... -
Proteostatic modulation in brain aging without associated Alzheimer's disease-and age-related neuropathological changes
Andrés Benito, Pol; Íñigo-Marco, Ignacio; Brullas, Marta; Carmona, Margarita; Del Rio, José Antonio; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Povedano, Mónica; Ferrer, Isidro (Impact Journals, 2023) Artículo / ArtikuluaAims: (Phospho)proteomics of old-aged subjects without cognitive or behavioral symptoms, and without ADneuropathological changes and lacking any other neurodegenerative alteration will increase understanding about the ... -
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory-entorhinal-amygdaloid axis in Alzheimer's and Parkinson's diseases
Cartas-Cejudo, Paz; Lachén Montes, Mercedes ; Ferrer, Isidro; Fernández Irigoyen, Joaquín; Santamaría, Enrique (BMC, 2023) Artículo / ArtikuluaBackground Smell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex diferences exist in terms of smell and olfactory structures as well as in the prevalence and ... -
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidro; Torre, Rafael de la; Robledo, Patricia (ACS Publications, 2020) Artículo / ArtikuluaThe Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ...