Listar por autor "Matilla Cuenca, Lara"

Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis

Matilla Cuenca, Lara; Martín Núñez, Ernesto; Garaikoetxea, Mattie; Navarro, Adela; Vico, Julieta Anabela; Arrieta Paniagua, Vanessa; García Peña, Amaia; Fernández Celis, Amaya; Gaínza Calleja, Alicia; Álvarez, Virginia; Sádaba Sagredo, Rafael; López Andrés, Natalia; Jover, Eva (Frontiers Media, 2022) Artículo / Artikulua

Objective: We aim to analyze sex-related differences in angiogenesis and lymphangiogenesis in aortic valves (AVs) and valve interstitial cells (VICs) from aortic stenosis (AS) patients. Approach and Results: Totally 230 ...

Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach

Martín Núñez, Ernesto; Goñi Olóriz, Miriam; Matilla Cuenca, Lara; Garaikoetxea Zubillaga, Mattie; Mourino-Álvarez, Laura; Navarro, Adela; Fernández Celis, Amaya; Tamayo Rodríguez, Ibai; Gaínza Calleja, Alicia; Álvarez, Virginia; Sádaba Sagredo, Rafael; Barderas, María G.; Jover, Eva; López Andrés, Natalia (Springer Nature, 2023) Artículo / Artikulua

Background: Diabetes mellitus (DM) accelerates the progression of aortic stenosis (AS), but how their underlying molecular mechanisms interact is not clear. Moreover, whether DM contributes to clinically relevant sex-differences ...

Sex differences in aortic stenosis. A role for the aldosterone/mineralocorticoid receptor axis and its biotarget Galectin-3

Matilla Cuenca, Lara (2023) Tesis doctoral / Doktoretza tesia

En esta tesis doctoral, se ha empleado una cohorte de pacientes con EA severa sometidos a cirugía de reemplazo valvular. El tejido valvular recibido se ha dividido para realizar estudios a nivel histológico, a nivel ...

Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis

Jover, Eva; Matilla Cuenca, Lara; Martín Núñez, Ernesto; Garaikoetxea Zubillaga, Mattie; Navarro, Adela; Fernández Celis, Amaya; Gaínza Calleja, Alicia; Arrieta Paniagua, Vanessa; García Peña, Amaia; Álvarez, Virginia; Sádaba Sagredo, Rafael; Jaisser, Frederic; López Andrés, Natalia (BMC, 2022) Artículo / Artikulua

Background: Accumulating evidence suggest the existence of sex-related differences in the pathogenesis of aortic stenosis (AS) with inflammation, oxidative stress, fibrosis and calcification being over-represented in men. ...

Soluble ST2 as a new oxidative stress and inflammation marker in metabolic syndrome

Roy, Ignacio; Jover, Eva; Matilla Cuenca, Lara; Álvarez, Virginia; Fernández Celis, Amaya; Beunza, Maite; Escribano, Elena; Gaínza Calleja, Alicia; Sádaba Sagredo, Rafael; López Andrés, Natalia (MDPI, 2023) Artículo / Artikulua

Background: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at ...

Targeting fatty acid-binding protein 4 improves pathologic features of aortic stenosis

Garaikoetxea, Mattie; Martín Núñez, Ernesto; Navarro, Adela; Matilla Cuenca, Lara; Fernández Celis, Amaya; Arrieta Paniagua, Vanessa; García Peña, Amaia; Gaínza Calleja, Alicia; Álvarez, Virginia; Sádaba Sagredo, Rafael; Jover, Eva; López Andrés, Natalia (MDPI, 2022) Artículo / Artikulua

Aortic stenosis (AS) is a fibrocalcific disease of the aortic valves (AVs). Sex-differences in AS pathophysiology have recently been described. High levels of fatty acid-binding protein 4 (FAPB4) in atherosclerotic plaques ...