Now showing items 1-14 of 14

    • Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis 

      Lachén Montes, Mercedes Upna Orcid; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ...
    • Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior 

      Herrero-Labrador, Raquel; Fernández Irigoyen, Joaquín Upna Orcid; Vecino, Rebeca; González-Arias, Canela; Ausín, Karina; Crespo, Inmaculada; Fernández Acosta, Francisco J.; Nieto-Estévez, Vanesa; Román, M. José; Perea, Gertrudis; Torres-Alemán, Ignacio; Santamaría, Enrique; Vicario, Carlos (Life Science Alliance, 2023)   Artículo / Artikulua  OpenAccess
      Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of ...
    • Deregulated transcription and proteostasis in adult mapt knockout mouse 

      Andrés Benito, Pol; Flores, África; Busquet-Areny, Sara; Carmona, Margarita; Ausín, Karina; Cartas Cejudo, Paz; Lachén Montes, Mercedes Upna Orcid; Río, José Antonio del; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ...
    • Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer's disease 

      Ferrer, Isidro; Andrés Benito, Pol; Ausín, Karina; Pamplona, Reinald; Río, José Antonio del; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Wiley, 2021)   Artículo / Artikulua  OpenAccess
      Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ...
    • Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease 

      Lachén Montes, Mercedes Upna Orcid; González Morales, Andrea Upna Orcid; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria Upna Orcid; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Frontiers Media, 2019)   Artículo / Artikulua  OpenAccess
      The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ...
    • Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy 

      Ferrer, Isidro; Andrés Benito, Pol; Zelaya Huerta, María Victoria Upna Orcid; Erro Aguirre, María Elena; Carmona, Margarita; Ausín, Karina; Lachén Montes, Mercedes Upna Orcid; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Río, José Antonio del (Springer, 2020)   Artículo / Artikulua  OpenAccess
      Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, ...
    • Mass spectrometry-based proteomic profiling of thrombotic material obtained by endovascular thrombectomy in patients with ischemic stroke 

      Muñoz, Roberto; Santamaría, Enrique; Rubio, Idoya; Ausín, Karina; Labarga, Alberto Upna Orcid (MDPI, 2018)   Artículo / Artikulua  OpenAccess
      Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein ...
    • Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions 

      Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Echaide Górriz, Míriam; Blanco, Ester; Chocarro, Luisa Upna Orcid; Toro, María de; Escors Murugarren, David; Fernández Irigoyen, Joaquín Upna Orcid; Kochan, Grazyna; Santamaría, Enrique (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
      One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ...
    • Network-driven proteogenomics unveils an aging-related imbalance in the olfactory IκBα-NFκB p65 complex functionality in Tg2576 Alzheimer’s disease mouse model 

      Palomino Alonso, Maialen; Lachén Montes, Mercedes Upna Orcid; González Morales, Andrea Upna Orcid; Ausín, Karina; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Olfaction is often deregulated in Alzheimer’s disease (AD) patients, and is also impaired in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little ...
    • Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) 

      Iridoy Zulet, Marina; Zubiri, Irene; Zelaya Huerta, María Victoria Upna Orcid; Martínez, Leire; Ausín, Karina; Lachén Montes, Mercedes Upna Orcid; Santamaría, Enrique; Fernández Irigoyen, Joaquín Upna Orcid; Jericó Pascual, Ivonne (MDPI, 2019)   Artículo / Artikulua  OpenAccess
      (1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common and differential mechanisms leading ...
    • Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies 

      Blanco, Ester; Silva-Pilipich, Noelia; Bocanegra Gondán, Ana Isabel; Chocarro, Luisa Upna Orcid; Procopio, Antonio; Ausín, Karina; Fernández Irigoyen, Joaquín Upna Orcid; Fernández Rubio, Leticia; Razquin, Nerea; Igea, Ana; Garnica, Maider; Echaide Górriz, Míriam; Arasanz Esteban, Hugo; Vera García, Ruth; Escors Murugarren, David; Smerdou, Cristian; Kochan, Grazyna (Springer Nature, 2024)   Artículo / Artikulua  OpenAccess
      Background: Previous studies have shown that functional systemic immunity is required for the efficacy of PD-1/PD-L1 blockade immunotherapies in cancer. Hence, systemic reprogramming of immunosuppressive dysfunctional ...
    • Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression 

      Lachén Montes, Mercedes Upna Orcid; González Morales, Andrea Upna Orcid; Zelaya Huerta, María Victoria Upna Orcid; Pérez Valderrama, Estela; Ausín, Karina; Ferrer, Isidro; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Springer Nature, 2017)   Artículo / Artikulua  OpenAccess
      Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- ...
    • A proteomic atlas of lineage and cancer-polarized expression modules in myeloid cells modeling immunosuppressive tumor-infiltrating subsets 

      Blanco, Ester; Ibáñez-Vea, María Upna Orcid; Hernández, Carlos; Drici, Lylia; Martínez de Morentin Iribarren, Xabier; Gato Cañas, María; Ausín, Karina; Bocanegra Gondán, Ana Isabel; Zuazo Ibarra, Miren Upna Orcid; Chocarro, Luisa Upna Orcid; Arasanz Esteban, Hugo; Fernández Hinojal, Gonzalo; Fernández Irigoyen, Joaquín Upna Orcid; Smerdou, Cristian; Garnica, Maider; Echaide Górriz, Míriam; Fernández Rubio, Leticia; Morente Sancho, Pilar; Ramos-Castellanos, Pablo; Llopiz, Diana; Santamaría, Enrique; Larsen, Martin R.; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Monocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to ...
    • Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism 

      Lachén Montes, Mercedes Upna Orcid; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidro; Torre, Rafael de la; Robledo, Patricia (ACS Publications, 2020)   Artículo / Artikulua  OpenAccess
      The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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