Now showing items 1-9 of 9

    • CDH22 hypermethylation is an independent prognostic biomarker in breast cancer 

      Martín Sánchez, Esperanza; Mendaza Lainez, Saioa Upna; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Blanco Luquin, Idoia; Cruz, Susana de la; Aramendia, Ana; Guerrero Setas, David (BioMed Central, 2017)   Artículo / Artikulua  OpenAccess
      Background: Cadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in ...
    • Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment 

      Celay Leoz, Ion Upna; Blanco Luquin, Idoia; Lázcoz, Paula Upna; Rotinen Díaz, Mirja Sofia Upna Orcid; Castresana, Javier S.; Encío Martínez, Ignacio Upna Orcid (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ...
    • CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer 

      Martín Sánchez, Esperanza; Mendaza Lainez, Saioa Upna; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Blanco Luquin, Idoia; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Pérez Janices, Noemi; Escors Murugarren, David; Megías, Diego (Impact Journals, 2017)   Artículo / Artikulua  OpenAccess
      The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation ...
    • Circular RNA expression profile in blood according to ischemic stroke etiology 

      Ostolaza, Aiora; Blanco Luquin, Idoia; Urdánoz Casado, Amaya Upna Orcid; Rubio, Idoya; Labarga, Alberto Upna Orcid (BioMed Central, 2020)   Artículo / Artikulua  OpenAccess
      Background: The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of ...
    • Gender-dependent deregulation of linear and circular RNA variants of homer1 in the entorhinal cortex of Alzheimer’s disease 

      Urdánoz Casado, Amaya Upna Orcid; Sánchez Ruiz de Gordoa, Javier Upna Orcid; Robles Solano, Maitane; Acha Santamaría, Blanca Upna Orcid; Roldán, Miren; Zelaya Huerta, María Victoria Upna Orcid; Blanco Luquin, Idoia; Mendióroz Iriarte, Maite (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      The HOMER1 gene is involved in synaptic plasticity, learning and memory. Recent studies show that circular RNA derived from HOMER1 (circHOMER1) expression is altered in some Alzheimer’s disease (AD) brain regions. In ...
    • Identificación de circRNAs como biomarcadores epigenéticos candidatos en la enfermedad de Alzheimer 

      Urdánoz Casado, Amaya Upna Orcid (2022)   Tesis doctoral / Doktoretza tesia
      La enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa, crónica y, por el momento, irreversible que representa la primera causa de demencia relacionada con la edad. Su diagnóstico sigue siendo un reto. En los ...
    • In vitro assessment of the role of p53 on chemotherapy treatments in neuroblastoma cell lines 

      Blanco Luquin, Idoia; Lázcoz, Paula Upna; Celay Leoz, Ion Upna; Castresana, Javier S.; Encío Martínez, Ignacio Upna Orcid (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Neuroblastoma is the most frequent malignant extracranial solid tumor of infancy. The overall objective of this work consists of determining the presence of alterations in the p53/MDM2 /p14ARF signaling pathway in neuroblastoma ...
    • NXN gene epigenetic changes in an adult neurogenesis model of Alzheimer's disease 

      Blanco Luquin, Idoia; Acha Santamaría, Blanca Upna Orcid; Urdánoz Casado, Amaya Upna Orcid; Gómez Orte, Eva; Roldán, Miren; Pérez Rodríguez, Diego R.; Cabello, Juan; Mendióroz Iriarte, Maite (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      In view of the proven link between adult hippocampal neurogenesis (AHN) and learning and memory impairment, we generated a straightforward adult neurogenesis in vitro model to recapitulate DNA methylation marks in the ...
    • Profile of TREM2-derived circRNA and mRNA variants in the entorhinal cortex of Alzheimer's disease patients 

      Urdánoz Casado, Amaya; Sánchez Ruiz de Gordoa, Javier; Robles, Maitane; Roldán, Miren; Zelaya Huerta, María Victoria Upna Orcid; Blanco Luquin, Idoia; Mendióroz Iriarte, Maite (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Genetic variants in TREM2, a microglia-related gene, are well-known risk factors for Alzheimer’s disease (AD). Here, we report that TREM2 originates from circular RNAs (circRNAs), a novel class of non-coding RNAs ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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