Listar por tema "Epigenetics"
Mostrando ítems 1-11 de 11
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Analysis of stemness gene expression and CD133 abnormal methylation in neuroblastoma cell lines
Neuroblastoma is the most common extracranial solid tumor in children, accounting for up to 10% of all childhood malignancies. Cellular heterogeneity is a hallmark of this embryonal cancer, as distinct neural crest lineages ... -
Búsqueda de nuevos biomarcadores epigenéticos en cáncer de mama triple negativo
Introducción El estudio de las alteraciones epigenéticas contribuye a la caracterización del subtipo triple negativo (TN) de cáncer de mama (CM). Objetivos Identificar genes diferencialmente metilados entre CM TN y ... -
Epigenetic regulation of microRNAs in cancer: shortening the distance from bench to bedside
Cancer is a complex disease involving alterations of multiple processes, with both genetic and epigenetic features contributing as core factors to the disease. In recent years, it has become evident that non-coding RNAs ... -
La epigenética como herramienta en el diagnóstico precoz de la enfermedad de Alzheimer (EA)
Antecedentes: la enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo con un patrón de afectación creciente, especialmente en población mayor de 65 años. El diagnóstico clínico de la enfermedad es tardío, lo que ... -
Exploring the conceptual challenges of integrating epigenetics in secondary-level science teaching
Rapidly occurring advancements in molecular genetics, such as recent developments in epigenetics, are challenging traditional genetics as it is taught at schools. For example, the adoption of epigenetics—which ... -
Identificación de circRNAs como biomarcadores epigenéticos candidatos en la enfermedad de Alzheimer
(2022) Tesis doctoral / Doktoretza tesiaLa enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa, crónica y, por el momento, irreversible que representa la primera causa de demencia relacionada con la edad. Su diagnóstico sigue siendo un reto. En los ... -
Induction of radiata pine somatic embryogenesis at high temperatures provokes a long-term decrease in DNA methylation/hydroxymethylation and differential expression of stress-related genes
Based on the hypothesis that embryo development is a crucial stage for the formation of stable epigenetic marks that could modulate the behaviour of the resulting plants, in this study, radiata pine somatic embryogenesis ... -
Methods for analysis of specific DNA methylation status
Methylation of CpG dinucleotides plays a crucial role in the regulation of gene expression and therefore in the development of different pathologies. Aberrant methylation has been associated to the majority of the diseases, ... -
Profile of TREM2-derived circRNA and mRNA variants in the entorhinal cortex of Alzheimer's disease patients
Genetic variants in TREM2, a microglia-related gene, are well-known risk factors for Alzheimer’s disease (AD). Here, we report that TREM2 originates from circular RNAs (circRNAs), a novel class of non-coding RNAs ... -
Transposon-associated epigenetic silencing during Pleurotus ostreatus life cycle
Transposable elements constitute an important fraction of eukaryotic genomes. Given their mutagenic potential, host-genomes have evolved epigenetic defense mechanisms to limit their expansion. In fungi, epigenetic modifications ... -
Tratamiento epigenético en personas con enfermedad de Parkinson (EP)
Contextualización: la enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común en la actualidad y la que mayor crecimiento tiene a nivel mundial. El diagnóstico y los tratamientos actuales se basan ...