Now showing items 1-6 of 6

    • Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens 

      Martínez, Isidoro; Oliveros, Juan C.; Cuesta, Isabel; Barrera, Jorge de la; Ausina, Vicente; Casals, Cristina; Lorenzo, Alba de; García, Ernesto; García Fojeda, Belén; Garmendia García, Juncal; González Nicolau, Mar; Lacoma, Alicia; Menéndez, Margarita; Moranta, David; Nieto, Amelia; Ortín, Juan; Pérez González, Alicia; Prat, Cristina; Ramos Sevillano, Elisa; Regueiro, Verónica; Rodríguez Frandsen, Ariel; Solís, Dolores; Yuste, José E.; Bengoechea Alonso, José Antonio; Melero, José A. (Frontiers Media, 2017)   Artículo / Artikulua  OpenAccess
      Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by ...
    • Deciphering tissue-induced Klebsiella pneumoniae lipid A structure 

      Llobet, Enrique; Martínez Moliner, Verónica; Moranta, David; Dahlström, Käthe M.; Regueiro, Verónica; Tomás, Anna; Cano, Victoria; Pérez Gutiérrez, Camino; Frank, Christian G.; Garmendia García, Juncal (National Academy of Sciences, 2015)   Artículo / Artikulua  OpenAccess
      The outcome of an infection depends on host recognition of the pathogen, hence leading to the activation of signaling pathways controlling defense responses. A long-held belief is that the modification of the lipid A ...
    • Genome expression profiling-based identification and administration efficacy of host-directed antimicrobial drugs against respiratory infection by nontypeable Haemophilus influenzae 

      Euba, Begoña; Moleres Apilluelo, Javier; Segura, Víctor; Viadas Martínez, Cristina Upna; Morey Sancho, Pau; Moranta, David; Leiva, José; Torres, Juan de; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (American Society for Microbiology, 2015)   Artículo / Artikulua  OpenAccess
      Therapies that are safe, effective, and not vulnerable to developing resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an antimicrobial approach alternative to conventional ...
    • Klebsiella pneumoniae outer membrane protein A is required to prevent the activation of airway epithelial cells 

      March, Catalina; Moranta, David; Regueiro, Verónica; Llobet, Enrique; Tomás, Anna; Garmendia García, Juncal; Bengoechea Alonso, José Antonio (American Society for Biochemistry and Molecular Biology, 2011)   Artículo / Artikulua  OpenAccess
      Outer membrane protein A (OmpA) is a class of proteins highly conserved among the Enterobacteriaceae family and throughout evolution. Klebsiella pneumoniae is a capsulated Gram-negative pathogen. It is an important cause ...
    • Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella 

      Insua, José Luis; Llobet, Enrique; Moranta, David; Pérez Gutiérrez, Camino; Tomás, Anna; Garmendia García, Juncal; Bengoechea, José A. (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      The implementation of infection models that approximate human disease is essential for understanding pathogenesis at the molecular level and for testing new therapies before they are entered into clinical stages. Insects ...
    • Role of bacterial surface structures on the interaction of Klebsiella pneumoniae with phagocytes 

      March, Catalina; Cano, Victoria; Moranta, David; Llobet, Enrique; Pérez Gutiérrez, Camino; Tomás, Juan M.; Suárez, Teresa; Garmendia, Junkal; Bengoechea Alonso, José Antonio (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      Phagocytosis is a key process of the immune system. The human pathogen Klebsiella pneumoniae is a well known example of a pathogen highly resistant to phagocytosis. A wealth of evidence demonstrates that the capsule ...