Browsing by Author "Muñoz, Jorge"

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Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma

Lázcoz, Paula ; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio ; Sáez Castresana, Javier (BioMed Central, 2006) Artículo / Artikulua

Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ...
Promoter methylation of RASSF1A associates to adult secondary glioblastomas and pediatric glioblastomas

Muñoz, Jorge; Inda, María del Mar; Lázcoz, Paula ; Zazpe, Idoya; Fan, Xing; Alfaro, Jorge; Tuñón Álvarez, Teresa; Rey, Juan A.; Castresana, Javier S. (Hindawi / Wiley, 2012) Artículo / Artikulua

While allelic losses and mutations of tumor suppressor genes implicated in the etiology of astrocytoma have been widely assessed, the role of epigenetics is still a matter of study. We analyzed the frequency of promoter ...