Now showing items 1-2 of 2

    • Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma 

      Lázcoz, Paula Upna; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio Upna Orcid; Sáez Castresana, Javier (BioMed Central, 2006)   Artículo / Artikulua  OpenAccess
      Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ...
    • Promoter methylation of RASSF1A associates to adult secondary glioblastomas and pediatric glioblastomas 

      Muñoz, Jorge; Inda, María del Mar; Lázcoz, Paula Upna; Zazpe, Idoya; Fan, Xing; Alfaro, Jorge; Tuñón Álvarez, Teresa; Rey, Juan A.; Castresana, Javier S. (Hindawi / Wiley, 2012)   Artículo / Artikulua  OpenAccess
      While allelic losses and mutations of tumor suppressor genes implicated in the etiology of astrocytoma have been widely assessed, the role of epigenetics is still a matter of study. We analyzed the frequency of promoter ...