Listar por tema "Proteomics"
Mostrando ítems 1-20 de 24
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Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease
(MDPI, 2022) Artículo / Artikulua
The relationship between Parkinson’s disease (PD), the second-most common neurodegenerative disease after Alzheimer’s disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this ... -
Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis
Lachén Montes, Mercedes
; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2020)
Artículo / Artikulua
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ... -
Bioinformatic approach for transcriptomics: integration of gene expression data based on RNA-seq with tissue localization
(2023) Trabajo Fin de Grado/Gradu Amaierako LanaOne of the main challenges in current system biology research comes when different types of data must be accessed from various sources, metrics and visualization and analysis tools. The challenge increases when it comes ... -
Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease
Lachén Montes, Mercedes ; González Morales, Andrea ; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria ; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Frontiers Media, 2019)
Artículo / Artikulua
The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ... -
Genomic, transcriptomic and proteomic analysis of Pleurotus ostreatus secreted proteins
Alfaro Sánchez, Manuel (2017)
Tesis doctoral / Doktoretza tesia
The objective of this thesis is to study the proteins secreted by the edible and worldwide cultivated white rot basidiomycete fungus Pleurotus ostreatus with three major goals: to determine the set of proteins secreted ... -
Glucose counteracts wood-dependent induction of lignocellulolytic enzyme secretion in monokaryon and dikaryon submerged cultures of the white-rot basidiomycete Pleurotus ostreatus
Alfaro Sánchez, Manuel ; Majcherczyk, A.; Kües, Ursula; Ramírez Nasto, Lucía ; Pisabarro de Lucas, Gerardo (Nature Research, 2020)
Artículo / Artikulua
The secretome complexity and lignocellulose degrading capacity of Pleurotus ostreatus monokaryons mkPC9 and mkPC15 and mated dikaryon dkN001 were studied in submerged liquid cultures containing wood, glucose, and wood plus ... -
The human gastric juice: a promising source for gastric cancer biomarkers
Felípez, Nayra; Montori, Sheyla; Mendizuri, Naroa; Llach, Joan; Delgado, Pedro G.; Moreira, Leticia; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Albéniz Arbizu, Eduardo (MDPI, 2023)
Artículo / Artikulua
Gastric cancer (GC) is a major public health problem worldwide, with high mortality rates due to late diagnosis and limited treatment options. Biomarker research is essential to improve the early detection of GC. Technological ... -
Human protein reference database as a discovery resource for proteomics
(Oxford University Press, 2004) Artículo / Artikulua
The rapid pace at which genomic and proteomic data is being generated necessitates the development of tools and resources for managing data that allow integration of information from disparate sources. The Human Protein ... -
Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
Andrés Benito, Pol; Povedano, Mónica; Domínguez Rubio, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020)
Artículo / Artikulua
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ... -
Local inhibition of nitrogen fixation and nodule metabolism in drought-stressed soybean
Gil Quintana, Erena; Larrainzar Rodríguez, Estíbaliz ; Seminario Huárriz, Amaia ; Díaz Leal, Juan Luis; Alamillo, Josefa M.; Pineda, Manuel; Arrese-Igor Sánchez, César ; Wienkoop, Stefanie; González García, Esther (Oxford University PressSociety for Experimental Biology, 2013)
Artículo / Artikulua
Drought stress is a major factor limiting symbiotic nitrogen fixation (NF) in soybean crop production. However, the regulatory mechanisms involved in this inhibition are still controversial. Soybean plants were symbiotically ... -
Mass spectrometry-based proteomic profiling of thrombotic material obtained by endovascular thrombectomy in patients with ischemic stroke
Muñoz, Roberto; Santamaría, Enrique; Rubio, Idoya; Ausín, Karina; Labarga, Alberto (MDPI, 2018)
Artículo / Artikulua
Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein ... -
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Echaide Górriz, Míriam; Blanco, Ester; Chocarro, Luisa ; Toro, María de; Escors Murugarren, David; Fernández Irigoyen, Joaquín ; Kochan, Grazyna; Santamaría, Enrique (Frontiers Media, 2022)
Artículo / Artikulua
One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ... -
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
Colomé, Núria; Abian, Joaquín; Aloria, Kerman; Arizmendi, Jesús M.; Barceló-Batllori, Silvia; Braga-Lagache, Sophie; Burlet-Schiltz, Odile; Carrascal, Montse; Casal, Ignacio J.; Chicano-Gálvez, Eduard; Chiva, Cristina; Clemente, Luis F.; Elortza, Félix; Estanyol, Josep M.; Fernández Irigoyen, Joaquín ; Fernández-Puente, Patricia; Fidalgo, María J.; Froment, Carine; Fuentes, Manuel; Fuentes-Almagro, Carlos; Gay, Marina; Hainard, Alexandre; Heller, Manfred; Hernández, María Luisa; Ibarrola, Nieves; Iloro, Ibon; Kieselbach, Thomas; Lario, Antonio; Locard-Paulet, Marie; Marina-Ramírez, Anabel; Martín, Luna; Morato-López, Esperanza; Muñoz, Javier; Navajas, Rosana; Odena, Antonia M.; Odriozola, Leticia; Oliveira, Eliandre de; Paradela, Alberto; Pasquarello, Carla; Rios, Vivian de los; Ruiz-Romero, Cristina; Sabidó, Eduard; Sánchez del Pino, Manuel; Sancho, Jaime; Santamaría, Enrique; Schaeffer-Reiss, Christine; Schneider, Justine; Torre, Carolina de la; Valero, Luz M.; Vilaseca, Marta; Wu, Shuai; Wu, Linfeng; Ximénez de Embún, Pilar; Canals, Francesc; Corrales, Fernando J.; ProteoRed-ISCIII; EuPA (Elsevier, 2022)
Artículo / Artikulua
Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that make ... -
Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
Iridoy Zulet, Marina; Zubiri, Irene; Zelaya Huerta, María Victoria ; Martínez, Leire; Ausín, Karina; Lachén Montes, Mercedes ; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Jericó Pascual, Ivonne (MDPI, 2019)
Artículo / Artikulua
(1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common and differential mechanisms leading ... -
New in vivo approach to broaden the thioredoxin family interactome in chloroplasts
Ancín Rípodas, María ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Larraya Reta, Luis María ; Fernández San Millán, Alicia ; Veramendi Charola, Jon ; Farrán Blanch, Inmaculada (MDPI, 2022)
Artículo / Artikulua
Post-translational redox modifications provide an important mechanism for the control of major cellular processes. Thioredoxins (Trxs), which are key actors in this regulatory mechanism, are ubiquitous proteins that catalyse ... -
Olfactory bulb proteomics reveals widespread proteostatic disturbances in mixed dementia and guides for potential serum biomarkers to discriminate alzheimer disease and mixed dementia phenotypes
Lachén Montes, Mercedes ; Íñigo-Marco, Ignacio; Cartas-Cejudo, Paz; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2021)
Artículo / Artikulua
The most common form of mixed dementia (MixD) is constituted by abnormal protein deposits associated with Alzheimer's disease (AD) that coexist with vascular disease. Although olfactory dysfunction is considered a clinical ... -
Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy
González Morales, Andrea ; Zabaleta, Aintzane; García Moure, Marc; Alonso Roldán, Marta ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Elsevier, 2018)
Artículo / Artikulua
Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection ... -
A proteomic view on the role of legume symbiotic interactions
Larrainzar Rodríguez, Estíbaliz ; Wienkoop, Stefanie (Frontiers Media, 2017)
Artículo / Artikulua
Legume plants are key elements in sustainable agriculture and represent a significant source of plant-based protein for humans and animal feed worldwide. One specific feature of the family is the ability to establish ... -
Quantitative proteomics reveals the importance of nitrogen source to control glucosinolate metabolism in Arabidopsis thaliana and Brassica oleracea
Marino Bilbao, Daniel ; Ariz, Idoia ; Lasa Larrea, Berta; Santamaría, Enrique; Aparicio Tejo, Pedro María (Oxford University Press, 2016)
Artículo / Artikulua
Accessing different nitrogen (N) sources involves a profound adaptation of plant metabolism. In this study, a quantitative proteomic approach was used to further understand how the model plant Arabidopsis thaliana adjusts ... -
Regulation of the response of plants to volatile compounds emitted by fungal phytopathogens
(2020) Tesis doctoral / Doktoretza tesia
El crecimiento y el desarrollo de las plantas están afectados por microorganismos presentes en la filosfera, la rizosfera y/o la endosfera. En la fase de precolonización, antes de que se establezca un contacto físico con ...
