Now showing items 1-9 of 9

    • Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis 

      Lachén Montes, Mercedes Upna Orcid; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín; Santamaría, Enrique (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ...
    • Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease 

      Lachén Montes, Mercedes Upna Orcid; González Morales, Andrea Upna Orcid; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín; Santamaría, Enrique (Frontiers Media, 2019)   Artículo / Artikulua  OpenAccess
      The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ...
    • Genomic, transcriptomic and proteomic analysis of Pleurotus ostreatus secreted proteins 

      Alfaro Sánchez, Manuel Upna Orcid (2017)   Tesis doctoral / Doktoretza tesia  OpenAccess
      The objective of this thesis is to study the proteins secreted by the edible and worldwide cultivated white rot basidiomycete fungus Pleurotus ostreatus with three major goals: to determine the set of proteins secreted ...
    • Human protein reference database as a discovery resource for proteomics 

      Peri, Suraj; Navarro, J. Daniel; Kristiansen, Troels Z.; Amanchy, Ramars; Surendranath, Vineeth; Muthusamy, Babylakshmi; Gandhi, T. K. B.; Chandrika, K. N.; Deshpande, Nandan; Suresh, Shubha; Rashmi, B. P.; Shanker, K.; Padma, N.; Niranjan, Vidya; Harsha, H. C.; Talreja, Naveen; Vrushabendra, B. M.; Ramya, M. A.; Yatish, A. J.; Joy, Mary; Shivashankar, H. N.; Kavitha, M. P.; Menezes, Minal; Choudhury, Dipanwita Roy; Ghosh, Neelanjana; Saravana, R.; Chandran, Sreenath; Mohan, Sujatha; Jonnalagadda, Chandra Kiran; Prasad, C. K.; Kumar-Sinha, Chandan; Deshpande, Krishna S.; Pandey, Akhilesh (Oxford University Press, 2004)   Artículo / Artikulua  OpenAccess
      The rapid pace at which genomic and proteomic data is being generated necessitates the development of tools and resources for managing data that allow integration of information from disparate sources. The Human Protein ...
    • Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis 

      Andrés Benito, Pol; Povedano, Mónica; Domínguez, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ...
    • Local inhibition of nitrogen fixation and nodule metabolism in drought-stressed soybean 

      Gil Quintana, Erena Upna; Larrainzar Rodríguez, Estíbaliz Upna Orcid; Seminario Huárriz, Amaia Upna; Díaz Leal, Juan Luis; Alamillo, Josefa M.; Pineda, Manuel; Arrese-Igor Sánchez, César Upna Orcid; Wienkoop, Stefanie; González García, Esther Upna Orcid (Oxford University PressSociety for Experimental Biology, 2013)   Artículo / Artikulua  OpenAccess
      Drought stress is a major factor limiting symbiotic nitrogen fixation (NF) in soybean crop production. However, the regulatory mechanisms involved in this inhibition are still controversial. Soybean plants were symbiotically ...
    • Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) 

      Iridoy Zulet, Marina; Zubiri, Irene; Zelaya Huerta, María Victoria; Martínez, Leire; Ausín, Karina; Lachén Montes, Mercedes Upna Orcid; Santamaría, Enrique; Fernández Irigoyen, Joaquín; Jericó Pascual, Ivonne (MDPI, 2019)   Artículo / Artikulua  OpenAccess
      (1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common and differential mechanisms leading ...
    • Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy 

      González Morales, Andrea Upna Orcid; Zabaleta, Aintzane; García Moure, Marc; Alonso Roldán, Marta Upna; Fernández Irigoyen, Joaquín; Santamaría, Enrique (Elsevier, 2018)   Artículo / Artikulua  OpenAccess
      Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection ...
    • A proteomic view on the role of legume symbiotic interactions 

      Larrainzar Rodríguez, Estíbaliz Upna Orcid; Wienkoop, Stefanie (Frontiers Media, 2017)   Artículo / Artikulua  OpenAccess
      Legume plants are key elements in sustainable agriculture and represent a significant source of plant-based protein for humans and animal feed worldwide. One specific feature of the family is the ability to establish ...