Browsing by Author "Sanmartín, Carmen"

Now showing items 1-6 of 6

    • A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells 

      Díaz, Marta; González, Roncesvalles; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen; Encío Martínez, Ignacio Upna (Wiley, 2017)   Artículo / Artikulua  OpenAccess
      Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide ...

    • Novel methylselenoesters as antiproliferative agents 

      Díaz Argelich, Nuria; Encío Martínez, Ignacio Upna; Plano, Daniel; Fernandes, Aristi P.; Palop, Juan Antonio; Sanmartín, Carmen (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...

    • Novel N,N′-disubstituted acylselenoureas as potential antioxidant and cytotoxic agents 

      Ruberte, Ana Carolina; Ramos Inza, Sandra; Aydillo, Carlos; Talavera, Irene; Encío Martínez, Ignacio Upna; Plano, Daniel; Sanmartín, Carmen (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, ...

    • Novel selenadiazole derivatives as selective antitumor and radical scavenging agents 

      Ruberte, Ana Carolina; Plano, Daniel; Encío Martínez, Ignacio Upna; Aydillo, Carlos; Sharma, Arun K.; Sanmartín, Carmen (Elsevier, 2018)   Artículo / Artikulua  OpenAccess
      Twenty-seven novel benzo[c][1,2,5]selenadiazole-5-carboxylic acid (BSCA) derivatives were designed and synthesized. Anti-proliferative activity of these structures was tested in vitro against a panel of five human cancer ...

    • Organoseleno cytostatic derivatives: autophagic cell death with AMPK and JNK activation 

      Garnica, Pablo; Encío Martínez, Ignacio Upna; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen (Elsevier Masson SAS, 2019)   Artículo / Artikulua
      Selenocyanates and diselenides are potential antitumor agents. Here we report two series of selenium derivatives related to selenocyanates and diselenides containing carboxylic, amide and imide moieties. These compounds ...

    • Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents 

      Sanmartín, Carmen; Plano, Daniel; Domínguez, Enrique; Font, María; Calvo, Alfonso; Prior, Celia; Encío Martínez, Ignacio Upna; Palop, Juan Antonio (MDPI, 2009)   Artículo / Artikulua  OpenAccess
      The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH(2)-COOH or Heterar-CO-Se-CH(2)-COOH are reported. The synthesis was carried ...

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