Now showing items 1-20 of 54

    • Absence of nuclear p16 is a diagnostic and independent prognostic biomarker in squamous cell carcinoma of the cervix 

      Mendaza Lainez, Saioa Upna; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Zudaire, Tamara; Guarch, Rosa; Guerrero Setas, David (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our ...
    • Alteration in the cerebrospinal fluid lipidome in Parkinson’s disease: a post-mortem pilot study 

      Fernández Irigoyen, Joaquín Upna Orcid; Cartas-Cejudo, Paz; Iruarrizaga-Lejarreta, Marta; Santamaría, Enrique (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Lipid metabolism is clearly associated to Parkinson’s disease (PD). Although lipid homeostasis has been widely studied in multiple animal and cellular models, as well as in blood derived from PD individuals, the cerebrospinal ...
    • Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease 

      Cervilla-Martínez Juan F.; Rodríguez-Gotor Juan J.; Wypijewski, Krzysztof J.; Fontán-Lozano Ángela; Wang, Tao; Santamaría, Enrique; Fuller, William; Mejías Rebeca (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      The relationship between Parkinson’s disease (PD), the second-most common neurodegenerative disease after Alzheimer’s disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this ...
    • Amyloid-driven tau accumulation on mitochondria potentially leads to cognitive deterioration in Alzheimer’s disease 

      Cuadrado-Tejedor, Mar; Pérez-González, Marta; Alfaro-Ruiz, Rocío; Badesso, Sara; Sucunza, Diego; Espelosín, María; Ursúa, Susana; Lachén Montes, Mercedes Upna Orcid; Fernández Irigoyen, Joaquín; Santamaría, Enrique; Luján, Rafael; García-Osta, Ana (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of Alzheimer’s disease, the interaction and specific contribution of each of them is not fully elucidated. To ...
    • Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis 

      Lachén Montes, Mercedes Upna Orcid; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ...
    • Biomarkers of delirium risk in older adults: a systematic review and meta-analysis 

      Lozano Vicario, Lucía; García Hermoso, Antonio; Cedeño Veloz, Bernardo Abel; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Romero Ortuno, Román; Zambom Ferraresi, Fabrício Upna Orcid; Sáez de Asteasu, Mikel L.; Muñoz-Vázquez, Ángel Javier; Izquierdo Redín, Mikel; Martínez Velilla, Nicolás (Frontiers Media, 2023)   Artículo / Artikulua  OpenAccess
      Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the ...
    • Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior 

      Herrero-Labrador, Raquel; Fernández Irigoyen, Joaquín Upna Orcid; Vecino, Rebeca; González-Arias, Canela; Ausín, Karina; Crespo, Inmaculada; Fernández Acosta, Francisco J.; Nieto-Estévez, Vanesa; Román, M. José; Perea, Gertrudis; Torres-Alemán, Ignacio; Santamaría, Enrique; Vicario, Carlos (Life Science Alliance, 2023)   Artículo / Artikulua  OpenAccess
      Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of ...
    • Deciphering CHFR role in pancreatic ductal adenocarcinoma 

      González Borja, Iranzu; Alors-Pérez, Emilia; Amat Villegas, Irene Upna; Alonso, Laura; Viyuela-García, Cristina; Goñi Irigoyen, Saioa Upna Orcid; Reyes, José C.; Ceballos-Chávez, María; Hernández García, Irene; Sánchez-Frías, Marina E.; Santamaría, Enrique; Razquin, Socorro; Arjona Sánchez, Álvaro; Arrazubi, Virginia; Pérez Sanz, Jairo; Vera García, Ruth; Fernández Irigoyen, Joaquín Upna Orcid; Castaño, Justo P.; Viúdez, Antonio (Frontiers Media, 2021)   Artículo / Artikulua  OpenAccess
      Checkpoint with forkhead-associated and ring finger domains (CHFR) has been proposed as a predictive and prognosis biomarker for different tumor types, but its role in pancreatic ductal adenocarcinoma (PDAC) remains unknown. ...
    • Deregulated transcription and proteostasis in adult mapt knockout mouse 

      Andrés Benito, Pol; Flores, África; Busquet-Areny, Sara; Carmona, Margarita; Ausín, Karina; Cartas Cejudo, Paz; Lachén Montes, Mercedes Upna Orcid; Río, José Antonio del; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ...
    • Docosahexaenoic acid ameliorates contextual fear memory deficits in the Tg2576 Alzheimer´s disease mouse model: cellular and molecular correlates 

      Badesso, Sara; Cartas-Cejudo, Paz; Espelosín, María; Santamaría, Enrique; Cuadrado-Tejedor, Mar; García-Osta, Ana (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Docosahexaenoic acid (DHA), the most abundant polyunsaturated fatty acid in the brain, is essential for successful aging. In fact, epidemiological studies have demonstrated that increased intake of DHA might lower the ...
    • Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer's disease 

      Ferrer, Isidro; Andrés Benito, Pol; Ausín, Karina; Pamplona, Reinald; Río, José Antonio del; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Wiley, 2021)   Artículo / Artikulua  OpenAccess
      Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ...
    • Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease 

      Lachén Montes, Mercedes Upna Orcid; González Morales, Andrea Upna Orcid; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria Upna Orcid; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Frontiers Media, 2019)   Artículo / Artikulua  OpenAccess
      The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ...
    • Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults 

      Cedeño Veloz, Bernardo Abel; Lozano Vicario, Lucía; Zambom Ferraresi, Fabrício Upna Orcid; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Rodríguez-García, Alba; Romero Ortuno, Román; Mondragón Rubio, Jaime; Ruiz-Ruiz, Javier; Ramírez Vélez, Robinson; Izquierdo Redín, Mikel; Martínez Velilla, Nicolás (BMC, 2023)   Artículo / Artikulua  OpenAccess
      Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ...
    • Effectiveness of a multicomponent exercise training program for the management of delirium in hospitalized older adults using near-infrared spectroscopy as a biomarker of brain perfusion: study protocol for a randomized controlled trial 

      Lozano Vicario, Lucía; Zambom Ferraresi, Fabíola Upna Orcid; Zambom Ferraresi, Fabrício Upna Orcid; Casa Marín, Antón de la; Ollo Martínez, Iranzu; López Sáez de Asteasu, Mikel; Cedeño Veloz, Bernardo Abel; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Romero Ortuno, Román; Izquierdo Redín, Mikel; Martínez Velilla, Nicolás (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
      Delirium is an important cause of morbidity and mortality in older adults admitted to hospital. Multicomponent interventions targeting delirium risk factors, including physical exercise and mobilization, have been shown ...
    • Estudio molecular de las células de glioblastoma multiforme tratadas con el adenovirus oncolítico Delta-24-RGD 

      González Morales, Andrea Upna Orcid (2019)   Tesis doctoral / Doktoretza tesia  OpenAccess
      El tratamiento del glioblastoma multiforme (GBM) con el adenovirus oncolítico Delta-24-RGD, ha demostrado ser seguro y específico. Esta nueva terapia contribuye a la remisión del tumor mediante diversos mecanismos, como ...
    • Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy 

      Ferrer, Isidro; Andrés Benito, Pol; Zelaya Huerta, María Victoria Upna Orcid; Erro Aguirre, María Elena; Carmona, Margarita; Ausín, Karina; Lachén Montes, Mercedes Upna Orcid; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Río, José Antonio del (Springer, 2020)   Artículo / Artikulua  OpenAccess
      Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, ...
    • Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection 

      Zubiate Orzanco, Pablo Upna Orcid; Urrutia Azcona, Aitor Upna Orcid; Ruiz Zamarreño, Carlos Upna Orcid; Egea Urra, Josune; Fernández Irigoyen, Joaquín Upna Orcid; Giannetti, Ambra; Baldini, Francesco; Díaz Lucas, Silvia Upna Orcid; Matías Maestro, Ignacio Upna Orcid; Arregui San Martín, Francisco Javier Upna Orcid; Santamaría, Enrique; Chiavaioli, Francesco; Del Villar, Ignacio Upna Orcid (Elsevier, 2019)   Artículo / Artikulua  OpenAccess
      D-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and ...
    • Fiber-based label-free D-dimer detection for early diagnosis of venous thromboembolism 

      Zubiate Orzanco, Pablo Upna Orcid; Urrutia Azcona, Aitor Upna Orcid; Ruiz Zamarreño, Carlos Upna Orcid; Fernández Irigoyen, Joaquín Upna Orcid; Giannetti, Ambra; Baldini, Francesco; Díaz Lucas, Silvia Upna Orcid; Matías Maestro, Ignacio Upna Orcid; Arregui San Martín, Francisco Javier Upna Orcid; Santamaría, Enrique; Del Villar, Ignacio Upna Orcid; Chiavaioli, Francesco (SPIE, 2020)   Contribución a congreso / Biltzarrerako ekarpena  OpenAccess
      D-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and ...
    • Host tau genotype specifically designs and regulates tau seeding and spreading and host tau transformation following intrahippocampal injection of identical tau AD inoculum 

      Andrés Benito, Pol; Carmona, Margarita; Jordán, Mónica; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Río, José Antonio del; Ferrer, Isidro (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Several studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. ...
    • The human gastric juice: a promising source for gastric cancer biomarkers 

      Felípez, Nayra; Montori, Sheyla; Mendizuri, Naroa; Llach, Joan; Delgado, Pedro G.; Moreira, Leticia; Santamaría, Enrique; Fernández Irigoyen, Joaquín Upna Orcid; Albéniz Arbizu, Eduardo (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Gastric cancer (GC) is a major public health problem worldwide, with high mortality rates due to late diagnosis and limited treatment options. Biomarker research is essential to improve the early detection of GC. Technological ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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