Browsing by Subject "Staphylococcus aureus"
Now showing items 1-20 of 24
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Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ... -
Bap, a Staphylococcus aureus surface protein involved in biofilm formation
Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ... -
Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus
The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ... -
Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ... -
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ... -
Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus
Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ... -
Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling
Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ... -
Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process
The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ... -
Functional analysis of the RNA chaperone CspA in Staphylococcus aureus
En esta tesis se pone de manifiesto que las chaperonas de RNA, como CspA, pueden interactuar de manera específica con estructuras de RNA, que a su vez pueden ser reconocidas por otras RBPs. Esto contribuye a un mejor ... -
Killing niche competitors by remote-control bacteriophage induction
A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by ... -
Near-infrared fluorescence imaging as an alternative to bioluminescent bacteria to monitor biomaterial-associated infections
Biomaterial-associated infection is one of the most common complications related with the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally ... -
Polymicrobial infections: do bacteria behave differently depending on their neighbours?
Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected ... -
Protein A-mediated multicellular behavior in Staphylococcus aureus
The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ... -
Puesta a punto de un método de análisis de virulencia de Staphylococcus aureus en Caenorhabditis elegans
La forma clásica para analizar la virulencia de los microorganismos patógenos humanos ha sido el empleo de modelos animales mamíferos. Desde hace algún tiempo, se han desarrollado modelos alternativos no mamíferos, como ... -
The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus
RNA-binding proteins (RBPs) are essential to finetune gene expression. RBPs containing the coldshock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for ... -
Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections
Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ... -
RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria
Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ... -
Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus
Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ... -
SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus
The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm formation ... -
Sensory deprivation in Staphylococcus aureus
Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...