Recent Submissions

  • The Navarra 1000 Genomes Project (NAGEN 1000): benefits for predictive, preventive and personalized medicine 

    Pasalodos, S.; Salgado, J.; Miranda, M.; Maíllo, A.; Matalonga, L.; Beltrán, S.; Carmona, R.; Pérez-Florido, J.; Etayo, G.; Lasheras, G.; Bernad, T.; Gómez-Cabrero, D.; Ángel-González, L.; Brennan, P.; Gut, I.; Dopazo, J.; Pinillos, I.; Lasa Uzcudun, Íñigo; Alonso Sánchez, Ángel Miguel (Springer, 2020)   Contribución a congreso / Biltzarrerako ekarpena  OpenAccess
    In the past few years, extraordinary developments in the field of next generation sequencing (NGS) technologies, such as whole genome sequencing (WGS), have made it possible for clinicians to have access to a huge amount ...
  • Pyk2 regulates MAMs and mitochondrial dynamics in hippocampal neurons 

    López-Molina, Laura; Fernández Irigoyen, Joaquín Upna Orcid; Cifuentes-Díaz, Carmen; Alberch, Jordi; Girault, Jean Antoine; Santamaría Martínez, Enrique; Ginés, Silvia; Giralt, Albert (MDPI, 2022)   Artículo / Artikulua  OpenAccess
    Pyk2 is a non-receptor tyrosine kinase enriched in hippocampal neurons, which can be activated by calcium-dependent mechanisms. In neurons, Pyk2 is mostly localised in the cytosol and dendritic shafts but can translocate ...
  • Sit to stand muscle power reference values and their association with adverse events in Colombian older adults 

    Ramírez Vélez, Robinson; Izquierdo Redín, Mikel; García Hermoso, Antonio; Ordóñez-Mora, Leidy T.; Cano Gutiérrez, Carlos Alberto; Campo-Lucumí, Florelba; Pérez Sousa, Miguel A.. (Nature Research, 2022)   Artículo / Artikulua  OpenAccess
    Recently, a valid method to assess lower-body muscle power based on a sit-to-stand feld test (STS) has been published. Our study aimed to describe lower-body muscle power in older individuals aged≥ 60 years and examine ...
  • Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy 

    Zuazo Ibarra, Miren Upna Orcid; Gato Cañas, María; Llorente, Noelia; Ibáñez Vea, María; Arasanz Esteban, Hugo; Kochan, Grazyna; Escors, David (AME Publishing, 2017)   Artículo / Artikulua  OpenAccess
    Programmed cell death-1 (PD1) has become a significant target for cancer immunotherapy. PD1 and its receptor programmed cell death 1 ligand 1 (PDL1) are key regulatory physiological immune checkpoints that maintain ...
  • PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity 

    Gato Cañas, María; Zuazo Ibarra, Miren Upna Orcid; Arasanz Esteban, Hugo; Ibañez Vea, Maria; Lorenzo, Laura; Fernandez-Hinojal, Gonzalo; Vera García, Ruth; Smerdou, Cristian; Martisova, Eva; Arozarena, Imanol; Wellbrock, Claudia; Llopiz, Diana; Ruiz, Marta; Sarobe, Pablo; Breckpot, Karine; Kochan, Grazyna; Escors, David (Elsevier, 2017)   Artículo / Artikulua  OpenAccess
  • PD1 signal transduction pathways in T cells 

    Arasanz Esteban, Hugo; Gato Cañas, María; Zuazo Ibarra, Miren Upna Orcid; Ibáñez-Vea, María Upna Orcid; Breckpot, Karine; Kochan, Grazyna; Escors, David (2017)   Artículo / Artikulua  OpenAccess
    The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating ...
  • PD-L1 expression in systemic immune cell populations as a potential predictive biomarker of responses to PD-L1/PD-1 blockade therapy in lung cancer 

    Bocanegra, Ana; Fernandez-Hinojal, Gonzalo; Zuazo Ibarra, Miren Upna Orcid; Arasanz Esteban, Hugo; Garcia-Granda, María Jesús; Hernandez, Carlos; Ibañez Vea, Maria; Hernandez-Marin, Berta; Martinez-Aguillo, Maite; Lecumberri, María José; Fernandez de Lascoiti, Ángela; Teijeira, Lucía; Morilla, idoia; Vera, Ruth; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2019)   Artículo / Artikulua  OpenAccess
    PD-L1 tumor expression is a widely used biomarker for patient stratification in PD-L1/PD-1 blockade anticancer therapies, particularly for lung cancer. However, the reliability of this marker is still under debate. Moreover, ...
  • Effects of exercise training on glycaemic control in youths with type 1 diabetes: a systematic review and meta-analysis of randomised controlled trials 

    García Hermoso, Antonio; Ezzatvar, Yasmin; Huerta-Uribe, Nidia; Alonso Martínez, Alicia Upna Orcid; Chueca-Guindulain, María J.; Berrade-Zubiri, Sara; Izquierdo Redín, Mikel; Ramírez Vélez, Robinson (Taylor & Francis, 2022)   Artículo / Artikulua  OpenAccess
    The aim of the study is to evaluate whether exercise interventions are associated with improved glycaemic control in children and adolescents with type 1 diabetes mellitus (T1DM), and to examine its relationship with the ...
  • Chemoreflex control as the cornerstone in immersion water sports: possible role on breath-hold 

    Arce Álvarez, Alexis; Salazar-Ardiles, Camila; Cornejo, Carlos; Páez, Valeria; Vásquez Muñoz, Manuel; Stillner-Vilches, Katherine; Jara, Catherine R.; Ramírez Campillo, Rodrigo; Izquierdo Redín, Mikel; Andrade, David C. (2022)   Artículo / Artikulua  OpenAccess
    Immersion water sports involve long-term apneas; therefore, athletes must physiologically adapt to maintain muscle oxygenation, despite not performing pulmonary ventilation. Breath-holding (i.e., apnea) is common in water ...
  • Prevalencia y evolución temporal de síntomas de asma en España. Estudio Global Asthma Network (GAN) 

    Bercedo Sanz, Alberto; Martínez-Torres, Antonela; González Díaz, Carlos; López-Silvarrey Varela, Ángel; Pellegrini Belinchón, Francisco Javier; Aguinaga Ontoso, Inés Upna Orcid; García-Marcos, Luis; Grupo GAN Espana (Asociación Española de Pediatría, 2022)   Artículo / Artikulua  OpenAccess
    Introduction: the temporal evolution of the prevalence of asthma described in the International Study of Asthma and Allergies in Childhood (ISAAC) in 2002 is unknown, or if the geographical or age differences are maintained ...
  • Passive or interactive virtual reality? The effectiveness for pain and anxiety reduction in pediatric patients 

    Ferraz Torres, Marta Upna Orcid; San Martín Rodríguez, Leticia Upna Orcid; García Vivar, Cristina Upna Orcid; Soto Ruiz, María Nelia Upna Orcid; Escalada Hernández, Paula Upna Orcid (Springer, 2022)   Artículo / Artikulua  OpenAccess
    Invasive techniques such as venipuncture are painful procedures causing stress and anxiety, both in pediatric patients and in their carers. For this reason, efforts are being made to develop mitigating strategies for the ...
  • Non-suicidal self-injury experiences for adolescents who self-injured: contributions of Winnicott's psychoanalytic theory 

    Cesar Riani Costa, Luiza; Martins Gabriel, Isabela; Oliveira, Wanderlei Abadio de; Hortense, Priscilla; López de Dicastillo Sáinz de Murieta, Olga Upna Orcid; Carlos, Diene Monique (Universidade Federal de Santa Catarina, 2021)   Artículo / Artikulua  OpenAccess
    Objective: to identify and analyze the elements present in non-suicidal self-injury experiences by adolescents who self-injured. Method: a qualitative research, with data collection conducted from August to October 2019 ...
  • Adherence of long-term breast cancer survivors to follow-up care guidelines: a study based on real-world data from the SURBCAN cohort 

    Santiá, Paula; Jansana, Anna; Cura, Isabel del; Padilla-Ruiz, María; Domingo, Laia; Louro, Javier; Comas, Mercé; Sanz, Teresa; Duarte-Salles, Talita; Redondo, Maximino; Ibáñez-Beroiz, B. Upna Orcid; Prados-Torres, Alexandra; Castells, Xavier; Sala, María (Springer, 2022)   Artículo / Artikulua  OpenAccess
    Purpose: to identify adherence to follow-up recommendations in long-term breast cancer survivors (LTBCS) of the SURBCAN cohort and to identify its determinants, using real-world data. Methods: we conducted a retrospective ...
  • Sedentary behaviors and risk of depression in the Seguimiento Universidad de Navarra cohort: the SUN Project 

    Pimenta, Adriano Marçal; Deus Mendonça, Raquel de; Lahortiga Ramos, Francisca; Fernandez-Lazaro, César I.; Martínez González, Miguel Ángel; Sánchez Villegas, María Almudena (Escola Nacional de Saude Pública Sergio Arouca, 2022)   Artículo / Artikulua  OpenAccess
    The study aimed to prospectively examine the association between different sedentary behaviors and the risk of depression. We included 12,691 Spanish university graduates (mean age: 36.7 year; SD: 11.5), participants of ...
  • Psychiatric hospitalization for attempted suicide and reattempt at the one-year follow-up 

    Goñi-Sarriés, Adriana; Yárnoz-Goñi, Nora; López-Goñi, José Javier Upna Orcid (Colegio Oficial de Psicólogos del Principado de Asturias, 2022)   Artículo / Artikulua  OpenAccess
    Antecedentes: las personas hospitalizadas por un intento de suicidio (IS) tienen un riesgo alto de repetir/consumar el suicidio en los meses siguientes al alta. El objetivo de este estudio es comparar un tratamiento habitual ...
  • Parálisis supranuclear progresiva: correlación clínico-patológica y aproximación al papel patogénico de lamicroglía 

    Sánchez Ruiz de Gordoa, Javier Upna Orcid (2022)   Tesis doctoral / Doktoretza tesia  OpenAccess
    La parálisis supranuclear progresiva (PSP) es una enfermedad neurodegenerativa que se manifiesta clínicamente como un parkinsonismo atípico y su base patológica son los depósitos de proteína tau en neuronas y células ...
  • Identificación de circRNAs como biomarcadores epigenéticos candidatos en la enfermedad de Alzheimer 

    Urdánoz Casado, Amaya Upna Orcid (2022)   Tesis doctoral / Doktoretza tesia
    La enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa, crónica y, por el momento, irreversible que representa la primera causa de demencia relacionada con la edad. Su diagnóstico sigue siendo un reto. En los ...
  • Papel de los sistemas de dos componentes de Staphylococcus aureus en la susceptibilidad a complestatina y corbomicina y en la regulación génica en ausencia de fosforilación 

    Gómez Arrebola, Carmen Upna Orcid (2022)   Tesis doctoral / Doktoretza tesia
    Staphylococcus aureus es una bacteria versátil que se puede encontrar estableciendo una relación comensal en la piel de, aproximadamente, el 30% de la población sin causar ningún problema. Sin embargo, cuando ésta atraviesa ...
  • Mediterranean diet and genetic determinants of obesity and metabolic syndrome in european children and adolescents 

    Seral-Cortes, Miguel; Larruy-García, Alicia; Miguel-Etayo, Pilar de; Labayen Goñi, Idoia Upna Orcid; Moreno, Luís A. (MDPI, 2022)   Artículo / Artikulua  OpenAccess
    Childhood obesity and metabolic syndrome (MetS) are multifactorial diseases influenced by genetic and environmental factors. The Mediterranean Diet (MD) seems to modulate the genetic predisposition to obesity or MetS in ...
  • TNF-α-secreting tumor-infiltrated monocytes play a pivotal role during anti-PD-L1 immunotherapy 

    Zuazo Ibarra, Miren Upna Orcid; Ridder, Kirsten de; Locy, Hanne; Piccioni, Elisa; Awad, Robin Maximilian; Verhulst, Stefaan; Van Bulck, Mathias; Vlaeminck, Yannick de; Lecoq, Quentin; Reijimen, Eva; Mey, Wout de; Beck, Lien de; Ertveldt, Thomas; Pintelon, Isabel; Timmermans, Jean-Pierre; Escors Murugarren, David; Keyaerts, Marleen; Breckpot, Karine; Goyvaerts, Cleo (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
    Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. ...

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