• Actionable driver events in small cell lung cancer 

      Gutiérrez Núñez, Mirian; Zamora Álvarez, Irene; Freeman, Michael R.; Encío Martínez,  Ignacio Upna Orcid; Rotinen Díaz, Mirja Sofia Upna Orcid (MDPI, 2024)   Artículo / Artikulua  OpenAccess
      Small cell lung cancer (SCLC) stands out as the most aggressive form of lung cancer, characterized by an extremely high proliferation rate and a very poor prognosis, with a 5-year survival rate that falls below 7%. ...
    • Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment 

      Celay Leoz, Ion Upna; Blanco Luquin, Idoia; Lázcoz, Paula Upna; Rotinen Díaz, Mirja Sofia Upna Orcid; Castresana, Javier S.; Encío Martínez, Ignacio Upna Orcid (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ...
    • Cutting down on lung cancer: Ecliptasaponin A is a novel therapeutic agent 

      Rotinen Díaz, Mirja Sofia Upna Orcid; Encío Martínez, Ignacio Upna Orcid (AME, 2020)   Artículo / Artikulua  OpenAccess
      This article is a comment of 'Han J, Lv W, Sheng H, et al. Ecliptasaponin A induces apoptosis through the activation of ASK1/JNK pathway and autophagy in human lung cancer cells. Ann Transl Med 2019;7:539'.
    • 'Defining the independence of the liver circadian clock' & 'BMAL1-driven tissue clocks respond independently to light to maintain homeostasis' 

      Rotinen Díaz, Mirja Sofia Upna Orcid (Frontiers Media, 2020)   Artículo / Artikulua  OpenAccess
      These studies demonstrate that peripheral tissues and organs can detect changes in environmental light and are capable of maintaining some basic functions, independently from our brain clock. The liver can autonomously ...
    • Scaffold attachment factor B1 regulates androgen degradation pathways in prostate cancer 

      Yang, Julie Suan-Wei; Qian, Chen; You, Sungyong; Rotinen Díaz, Mirja Sofia Upna Orcid; Posadas, Edwin M.; Freedland, Stephen J.; Di Vizio, Dolores; Kim, Jayoung; Freeman, Michael R. (E-Century Publishing, 2021)   Artículo / Artikulua  OpenAccess
      The nuclear matrix protein Scaffold Attachment Factor B1 (SAFB1, SAFB) can act in prostate cancer (PCa) as an androgen receptor (AR) co-repressor that functions through epigenetic silencing of AR targets, such as prostate ...
    • Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells 

      Rotinen Díaz, Mirja Sofia Upna Orcid; Villar Bécares, Joaquín Upna; Celay Leoz, Ion Upna; Serrano Mendioroz, Irantzu Upna; Notario, Vicente; Encío Martínez, Ignacio Upna Orcid (Elsevier, 2011)   Artículo / Artikulua  OpenAccess
      Type 11 Hydroxysteroid (17-beta) dehydrogenase (HSD17B11) catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone suggesting that it may play an important role in androgen metabolism. We previously described ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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