• Anti-biofilm molecules targeting functional amyloids 

      Matilla Cuenca, Leticia Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing ...
    • Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids 

      Matilla Cuenca, Leticia Upna Orcid; Gil Puig, Carmen Upna Orcid; Cuesta Ferre, Sergio; Rapún Araiz, Beatriz Upna Orcid; Mira, Alex; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Ziemité, Miglé (Nature Research, 2020)   Artículo / Artikulua  OpenAccess
      The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ...
    • Bacterial biofilm functionalization through Bap amyloid engineering 

      Matilla Cuenca, Leticia Upna Orcid; Taglialegna, Agustina Upna; Gil Puig, Carmen Upna Orcid; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione Upna Orcid (Springer Nature, 2022)   Artículo / Artikulua  OpenAccess
      Biofilm engineering has emerged as a controllable way to fabricate living structures with programmable functionalities. The amyloidogenic proteins comprising the biofilms can be engineered to create self-assembling ...
    • The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers 

      Taglialegna, Agustina Upna; Matilla Cuenca, Leticia Upna Orcid; Dorado Morales, Pedro Upna Orcid; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (Nature ResearchNanyang Technological University (Singapur), 2020)   Artículo / Artikulua  OpenAccess
      Functional amyloids are considered as common building block structures of the biofilm matrix in different bacteria. In previous work, we have shown that the staphylococcal surface protein Bap, a member of the Biofilm-Associated ...
    • Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch 

      Ma, Junfeng; Cheng, Xiang; Xu, Zhonghe; Zhang, Yikan; Valle Turrillas, Jaione Upna Orcid; Fan, Xianyang; Lasa Uzcudun, Íñigo Upna Orcid (EMBO Press, 2021)   Artículo / Artikulua  OpenAccess
      The Staphylococcal Bap proteins sense environmental signals (such as pH, [Ca2+]) to build amyloid scaffold biofilm matrices via unknown mechanisms. We here report the crystal structure of the aggregation-prone region of ...
    • A systematic evaluation of the two-component systems network reveals that ArlRS is a key regulator of catheter colonization by Staphylococcus aureus 

      Burgui Erice, Saioa Upna Orcid; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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