Listar Artículos de revista DCS - OZS Aldizkari artikuluak por tema "Selenium"
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Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: identification of a Se-indomethacin analog as a potential therapeutic for breast cancer
A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of selenoester were reported. Twenty Se-NSAID ... -
New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer
Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA ... -
Novel acylselenourea derivatives: dual molecules with anticancer and radical scavenging activity
Oxidative stress surrounding cancer cells provides them with certain growth and survival advantages necessary for disease progression. In this context, Se-containing molecules have gained attention due to their anticancer ... -
Novel N,N′-disubstituted acylselenoureas as potential antioxidant and cytotoxic agents
Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, ... -
Novel selenadiazole derivatives as selective antitumor and radical scavenging agents
Twenty-seven novel benzo[c][1,2,5]selenadiazole-5-carboxylic acid (BSCA) derivatives were designed and synthesized. Anti-proliferative activity of these structures was tested in vitro against a panel of five human cancer ... -
Seleno-analogs of scaffolds resembling natural products a novel warhead toward dual compounds
Nowadays, oxidative cell damage is one of the common features of cancer and Alzheimer’s disease (AD), and Se-containing molecules, such as ebselen, which has demonstrated strong antioxidant activity, have demonstrated ... -
Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential
Currently, cancer, leishmaniasis and bacterial infections represent a serious public health burden worldwide. Six cinnamyl and benzodioxyl derivatives incorporating selenium (Se) as selenocyanate, diselenide, or selenide ...