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Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents
(MDPI, 2009)
Artículo / Artikulua,
The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH(2)-COOH or Heterar-CO-Se-CH(2)-COOH are reported. The synthesis was carried ...
New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer
(MDPI, 2020)
info:eu-repo/semantics/article,
Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA ...
Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential
(MDPI, 2022)
Artículo / Artikulua,
Currently, cancer, leishmaniasis and bacterial infections represent a serious public health burden worldwide. Six cinnamyl and benzodioxyl derivatives incorporating selenium (Se) as selenocyanate, diselenide, or selenide ...
Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: identification of a Se-indomethacin analog as a potential therapeutic for breast cancer
(Elsevier, 2022)
Artículo / Artikulua,
A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of selenoester were reported. Twenty Se-NSAID ...
Novel methylselenoesters as antiproliferative agents
(MDPI, 2017)
Artículo / Artikulua,
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...
Novel N,N′-disubstituted acylselenoureas as potential antioxidant and cytotoxic agents
(MDPI, 2020)
info:eu-repo/semantics/article,
Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, ...