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Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
(Nature Research, 2020)
Artículo / Artikulua,
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the
aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS)
that determines bacterial ...
Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids
(Nature Research, 2020)
info:eu-repo/semantics/article,
The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ...
Operones no-contiguos: una nueva estrategia para coordinar la expresión de genes en bacterias
(2020)
info:eu-repo/semantics/doctoralThesis,
En esta tesis demostramos la existencia de un nivel superior de organización en la estructura del operón que denominamos operón no-contiguo y que consiste en un operón que contiene un gen o genes que se transcriben en la ...
Caracterización del sistema sensorial de dos componentes de Staphylococcus aureus
(2020)
info:eu-repo/semantics/doctoralThesis,
En este trabajo de tesis hemos evaluado dos aproximaciones diferentes dedicadas a la búsqueda de fármacos que tengan como diana de acción los TCSs. Por un lado, dentro del proyecto 'Nuevas estrategias para el control de ...
Functional specificity and post-transcriptional regulation of the cold shock proteins in Staphylococcus aureus
(2020)
info:eu-repo/semantics/doctoralThesis,
En esta Tesis se han descifrado aspectos relevantes sobre las funciones de las proteínas CSPs de Staphylococcus aureus y su regulación, que pueden ser extrapoladas a otras bacterias. Específicamente, demostramos que sólo ...
Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus
(American Society for Microbiology, 2020)
info:eu-repo/semantics/article,
In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different ...
The impact of two-component sensorial network in staphylococcal speciation
(Elsevier, 2020)
info:eu-repo/semantics/article,
Bacteria use two-component systems (TCSs) to sense and respond to their environments. Free-living bacteria usually contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. ...