• Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

      Cucarella, C.; Solano Goñi, Cristina Upna; Valle Turrillas, Jaione Upna; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...
    • Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus 

      Arrizubieta, M. J.; Toledo Arana, Alejandro Upna; Amorena Zabalza, Beatriz Upna; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ...
    • Characterization of ovine A3Z1 restriction properties against small ruminant lentiviruses (SRLVs) 

      Pablo Maiso, Lorena de; Glaría Ezquer, Idoia Upna; Crespo, Helena Upna; Nistal Villán, Estanislao; Andrésdóttir, Valgerdur; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine deamination ...
    • Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep 

      Salazar, Eider; Monleón, Eva; Bolea, Rosa; Acín, Cristina; Pérez, Marta; Álvarez, Neila; Leginagoikoa, Iratxe; Juste, Ramón; Minguijón, Esmeralda; Reina Arias, Ramsés Upna; Glaría Ezquer, Idoia Upna; Berriatua, Eduardo; Andrés Cara, Damián de Upna; Badiola, Juan José; Amorena Zabalza, Beatriz Upna; Luján, Lluís (EDP Sciences, 2010)   Artículo / Artikulua  OpenAccess
      There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV ...
    • The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

      Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Solano Goñi, Cristina Upna; Arrizubieta Balerdi, María Jesús; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz Upna; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...
    • Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process 

      Cucarella, Carme; Tormo, M. Ángeles; Knecht, Erwin; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Foster, Timothy J.; Penadés, José R. (American Society for Microbiology, 2002)   Artículo / Artikulua  OpenAccess
      The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ...
    • Extensive rearing hinders Maedi-Visna Virus (MVV) infection in sheep 

      Leginagoikoa, Iratxe; Juste, Ramón; Barandika, Jesse; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Luján, Lluís; Badiola, Juan José; Berriatua, Eduardo (EDP Sciences, 2006)   Artículo / Artikulua  OpenAccess
      Maedi-Visna Virus (MVV) seroprevalence and its relationship with housing and mode of rearing of replacement ewe-lambs was investigated in 38 non-randomly selected sheep-flocks in Spain. They included extensive lamb-producing ...
    • The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice 

      San Román Aberasturi, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Lasarte, Juan José; Grilló Dolset, María Jesús; Garrido, Victoria Upna; Muñoz Álvaro, Pilar María; Arribillaga, Laura; García Martínez, Begoña Upna; Andrés, Ximena de; Zabaleta, Virginia Upna; Mansilla, Cristina; Farrán Blanch, Inmaculada Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      The Extradomain A from fibronectin (EDA) has an immunomodulatory role as fusion protein with viral and tumor antigens, but its effect when administered with bacteria has not been assessed. Here, we investigated the adjuvant ...
    • Identification of the ovine mannose receptor and its possible role in Visna/Maedi virus infection 

      Crespo, Helena Upna; Reina Arias, Ramsés Upna; Glaría Ezquer, Idoia Upna; Ramírez, Hugo Upna; Andrés, Ximena de; Jauregui, Paula; Luján, Lluís; Martínez Pomares, Luisa; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna (BioMed Central, 2011)   Artículo / Artikulua  OpenAccess
      This study aims to characterize the mannose receptor (MR) gene in sheep and its role in ovine visna/maedi virus (VMV) infection. The deduced amino acid sequence of ovine MR was compatible with a transmembrane protein having ...
    • Immunization against small ruminant lentiviruses 

      Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered ...
    • In vivo monitoring of Staphylococcus aureus biofilm infections and antimicrobial therapy by [18F]fluoro-deoxyglucose–MicroPET in a mouse model 

      Garrido, Victoria Upna; Collantes, María; Barberán, Montserrat; Peñuelas, Iván; Arbizu, Javier; Amorena Zabalza, Beatriz Upna; Grilló Dolset, María Jesús (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      A mouse model was developed for in vivo monitoring of infection and the effect of antimicrobial treatment against Staphylococcus aureus biofilms, using the [18F]fluoro-deoxyglucose–MicroPET ([18F]FDG-MicroPET) image ...
    • Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers 

      Salazar, Eider; Berriatua, Eduardo; Pérez, Marta; Marín, Belén; Acin, Cristina; Martín Burriel, Inmaculada; Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Badiola, Juan José; Luján, Lluís (Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA), 2014)   Artículo / Artikulua  OpenAccess
      The relationship between Visna/maedi virus (VMV) antibody status and scrapie genetic resistance of 10,611 Rasa Aragonesa sheep from 17 flocks in Aragón (Spain) was investigated. The fifteen most common PRNP gene haplotypes and ...
    • Maedi-visna virus infection of ovine mammary epithelial cells 

      Bolea, Rosa; Monleón, Eva; Carrasco, Librado; Vargas, Antonia; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Badiola, Juan José; Luján, Lluís (EDP Sciences, 2006)   Artículo / Artikulua  OpenAccess
      The aim of this work was to perform a complete study of maedi-visna virus (MVV) infected mammary glands of naturally-infected sheep, and to determine if cells other than macrophages undergo a productive viral infection in ...
    • Mannose receptor may be involved in small ruminant lentivirus pathogenesis 

      Crespo, Helena Upna; Jauregui, Paula; Glaría Ezquer, Idoia Upna; Sanjosé, Leticia; Polledo, Laura; García Marín, Juan F.; Luján, Lluís; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) ...
    • Ovine TRIM5α can restrict visna/maedi virus 

      Jauregui, Paula; Crespo, Helena Upna; Glaría Ezquer, Idoia Upna; Luján, Lluís; Contreras, A.; Rosati, Sergio; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Towers, G. J.; Reina Arias, Ramsés Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ...
    • Post-entry blockade of small ruminant lentiviruses by wild ruminants 

      Sanjosé, Leticia; Crespo, Helena Upna; Blatti-Cardinaux, Laure; Glaría Ezquer, Idoia Upna; Martínez Carrasco, Carlos; Berriatua, Eduardo; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Bertoni, Giuseppe; Reina Arias, Ramsés Upna (BioMed Central, 2016)   Artículo / Artikulua  OpenAccess
      Small ruminant lentivirus (SRLV) infection causes losses in the small ruminant industry due to reduced animal production and increased replacement rates. Infection of wild ruminants in close contact with infected domestic ...
    • Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus 

      Cucarella, Carme; Tormo, M. Ángeles; Ubeda, Carles; Trotonda, M. Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna; Penadés, José R. (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ...
    • Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes 

      Peterhans, Ernst; Greenland, Tim; Badiola, Juan; Harkiss, Gordon; Bertoni, Giuseppe; Amorena Zabalza, Beatriz Upna; Eliaszewicz, Muriel; Juste, Ramón; Krassnig, Renate; Lafont, Jean Pierre (EDP Sciences, 2004)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV = maedi-visna in sheep and caprine arthritis encephalitis in goats) are distributed throughout most countries of the world, particularly Europe. Laboratories from 16 European countries ...
    • Small ruminant lentiviruses: genetic variability, tropism and diagnosis 

      Ramírez, Hugo Upna; Reina Arias, Ramsés Upna; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Martínez, Humberto A. (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) cause a multisystemic chronic disease affecting animal production and welfare. SRLV infections are spread across the world with the exception of Iceland. Success in controlling SRLV spread ...
    • Small ruminant macrophage polarization may play a pivotal role on lentiviral infection 

      Crespo, Helena Upna; Bertolotti, Luigi; Juganaru, Magda; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Rosati, Sergio; Reina Arias, Ramsés Upna (BioMed Central, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal ...