Browsing Artículos de revista IdAB - IdAB Aldizkari artikuluak by UPNA Author "Toledo Arana, Alejandro"
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Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
Valle Turrillas, Jaione
; Latasa Osta, Cristina ; Gil Puig, Carmen ; Toledo Arana, Alejandro ; Solano Goñi, Cristina ; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)
Artículo / Artikulua 
The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ... -
Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus
Ruiz de los Mozos Aliaga, Igor; Vergara Irigaray, Marta ; Segura, Víctor; Villanueva San Martín, Maite ; Bitarte, Nerea ; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro (Public Library of Science, 2013)
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The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ... -
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil Puig, Carmen ; Solano Goñi, Cristina ; Burgui Erice, Saioa ; Latasa Osta, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (American Society for Microbiology, 2014)
Artículo / Artikulua
The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ... -
Biofilm switch and immune response determinants at early stages of infection
Valle Turrillas, Jaione ; Solano Goñi, Cristina ; García Martínez, Begoña ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (Elsevier (Cell Press), 2013)
Artículo / Artikulua
Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ... -
Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus
Arrizubieta Balerdi, María Jesús; Toledo Arana, Alejandro ; Amorena Zabalza, Beatriz ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2004)
Artículo / Artikulua
Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ... -
Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose
Zorraquino Salvo, Violeta; García Martínez, Begoña ; Latasa Osta, Cristina ; Echeverz Sarasúa, Maite ; Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Lasa Uzcudun, Íñigo ; Solano Goñi, Cristina (American Society for Microbiology, 2013)
Artículo / Artikulua
Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ... -
An effort to make sense of antisense transcription in bacteria
Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro ; Gingeras, Thomas R. (Taylor & Francis, 2012)
Artículo / Artikulua
Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some ... -
The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation
Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Arrizubieta Balerdi, María Jesús ; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz ; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2001)
Artículo / Artikulua
The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ... -
Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling
Valle Turrillas, Jaione ; Burgui Erice, Saioa ; Langheinrich, Denise; Gil Puig, Carmen ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo (2015)
Artículo / Artikulua
Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ... -
Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella
Solano Goñi, Cristina ; García Martínez, Begoña ; Latasa Osta, Cristina ; Toledo Arana, Alejandro ; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione ; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo (National Academy of Sciences, 2009)
Artículo / Artikulua
Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ... -
Genome-wide antisense transcription drives mRNA processing in bacteria
Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro ; Dobin, Alexander; Villanueva San Martín, Maite ; Ruiz de los Mozos Aliaga, Igor ; Vergara Irigaray, Marta ; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Gingeras, Thomas R. (National Academy of Sciences, 2011)
Artículo / Artikulua
RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ... -
Noncontiguous operon is a genetic organization for coordinating bacterial gene expression
Sáenz Lahoya, S.; Bitarte, Nerea; García, Beñat; Burgui Erice, Saioa ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (National Academy of Sciences, 2019)
Artículo / Artikulua
Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization ... -
Protein A-mediated multicellular behavior in Staphylococcus aureus
Merino, Nekane; Toledo Arana, Alejandro ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2008)
Artículo / Artikulua
The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ... -
The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus
Caballero Sánchez, Carlos; Menéndez Gil, Pilar; Catalán Moreno, Arancha; Vergara Irigaray, Marta ; García Martínez, Begoña ; Segura, Víctor; Irurzun Domínguez, Naiara; Villanueva San Martín, Maite ; Ruiz de los Mozos Aliaga, Igor ; Solano Goñi, Cristina ; Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro (Oxford University Press, 2018)
Artículo / Artikulua
RNA-binding proteins (RBPs) are essential to finetune gene expression. RBPs containing the coldshock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for ... -
Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections
Vergara Irigaray, Marta; Valle Turrillas, Jaione ; Merino, Nekane ; Latasa Osta, Cristina ; García Martínez, Begoña ; Ruiz de los Mozos Aliaga, Igor ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2009)
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Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ... -
Salmonella biofilm development depends on the phosphorylation status of RcsB
Latasa Osta, Cristina; García Martínez, Begoña ; Echeverz Sarasúa, Maite ; Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina ; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2012)
Artículo / Artikulua
The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ... -
Sensory deprivation in Staphylococcus aureus
Villanueva San Martín, Maite ; García Martínez, Begoña ; Valle Turrillas, Jaione ; Rapún Araiz, Beatriz ; Ruiz de los Mozos Aliaga, Igor ; Solano Goñi, Cristina ; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (Springer Nature, 2018)
Artículo / Artikulua
Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ... -
Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system
Toledo Arana, Alejandro ; Merino, Nekane ; Vergara Irigaray, Marta ; Débarbouillé, Michel; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2005)
Artículo / Artikulua
The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation capacity ... -
A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria
Quiles Puchalt, Nuria; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Toledo Arana, Alejandro ; Monedero, Vicente; Lasa Uzcudun, Íñigo ; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2013)
Artículo / Artikulua
The propagation of bacteriophages and other mobile genetic elements requires exploitation of the phage mechanisms involved in virion assembly and DNA packaging. Here, we identified and characterized four different families ... -
Wavelet-based detection of transcriptional activity on a novel Staphylococcus aureus tiling microarray
Segura, Víctor; Toledo Arana, Alejandro ; Uzqueda, Maite; Lasa Uzcudun, Íñigo ; Muñoz Barrutia, Arrate (BioMed Central, 2012)
Artículo / Artikulua
Background: High-density oligonucleotide microarray is an appropriate technology for genomic analysis, and is particulary useful in the generation of transcriptional maps, ChIP-on-chip studies and re-sequencing of the ...
