• Characterization of ovine A3Z1 restriction properties against small ruminant lentiviruses (SRLVs) 

      Pablo Maiso, Lorena de; Glaría Ezquer, Idoia Upna; Crespo, Helena Upna; Nistal Villán, Estanislao; Andrésdóttir, Valgerdur; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine deamination ...
    • Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep 

      Salazar, Eider; Monleón, Eva; Bolea, Rosa; Acín, Cristina; Pérez, Marta; Álvarez, Neila; Leginagoikoa, Iratxe; Juste, Ramón; Minguijón, Esmeralda; Reina Arias, Ramsés Upna; Glaría Ezquer, Idoia Upna; Berriatua, Eduardo; Andrés Cara, Damián de Upna; Badiola, Juan José; Amorena Zabalza, Beatriz Upna; Luján, Lluís (EDP Sciences, 2010)   Artículo / Artikulua  OpenAccess
      There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV ...
    • Identification of the ovine mannose receptor and its possible role in Visna/Maedi virus infection 

      Crespo, Helena Upna; Reina Arias, Ramsés Upna; Glaría Ezquer, Idoia Upna; Ramírez, Hugo Upna; Andrés, Ximena de; Jauregui, Paula; Luján, Lluís; Martínez Pomares, Luisa; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna (BioMed Central, 2011)   Artículo / Artikulua  OpenAccess
      This study aims to characterize the mannose receptor (MR) gene in sheep and its role in ovine visna/maedi virus (VMV) infection. The deduced amino acid sequence of ovine MR was compatible with a transmembrane protein having ...
    • Immunization against small ruminant lentiviruses 

      Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered ...
    • Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers 

      Salazar, Eider; Berriatua, Eduardo; Pérez, Marta; Marín, Belén; Acín, Cristina; Martín Burriel, Inmaculada; Reina Arias, Ramsés Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Badiola, Juan José; Luján, Lluís (Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA), 2014)   Artículo / Artikulua  OpenAccess
      The relationship between Visna/maedi virus (VMV) antibody status and scrapie genetic resistance of 10,611 Rasa Aragonesa sheep from 17 flocks in Aragón (Spain) was investigated. The fifteen most common PRNP gene haplotypes and ...
    • Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit 

      Crespo, Helena Upna; Guillén, Hugo; Pablo Maiso, Lorena de; Gómez Arrebola, Carmen; Rodríguez, Gregorio; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna; Reina Arias, Ramsés Upna (Taylor & Francis, 2017)   Artículo / Artikulua  OpenAccess
      β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained ...
    • Mannose receptor may be involved in small ruminant lentivirus pathogenesis 

      Crespo, Helena Upna; Jauregui, Paula; Glaría Ezquer, Idoia Upna; Sanjosé, Leticia; Polledo, Laura; García Marín, Juan F.; Luján, Lluís; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) ...
    • Ovine TRIM5α can restrict visna/maedi virus 

      Jauregui, Paula; Crespo, Helena Upna; Glaría Ezquer, Idoia Upna; Luján, Lluís; Contreras, A.; Rosati, Sergio; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Towers, G. J.; Reina Arias, Ramsés Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ...
    • Post-entry blockade of small ruminant lentiviruses by wild ruminants 

      Sanjosé, Leticia; Crespo, Helena Upna; Blatti-Cardinaux, Laure; Glaría Ezquer, Idoia Upna; Martínez Carrasco, Carlos; Berriatua, Eduardo; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Bertoni, Giuseppe; Reina Arias, Ramsés Upna (BioMed Central, 2016)   Artículo / Artikulua  OpenAccess
      Small ruminant lentivirus (SRLV) infection causes losses in the small ruminant industry due to reduced animal production and increased replacement rates. Infection of wild ruminants in close contact with infected domestic ...
    • Small ruminant lentiviruses: genetic variability, tropism and diagnosis 

      Ramírez, Hugo Upna; Reina Arias, Ramsés Upna; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna; Martínez, Humberto A. (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) cause a multisystemic chronic disease affecting animal production and welfare. SRLV infections are spread across the world with the exception of Iceland. Success in controlling SRLV spread ...
    • Small ruminant macrophage polarization may play a pivotal role on lentiviral infection 

      Crespo, Helena Upna; Bertolotti, Luigi; Juganaru, Magda; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna; Amorena Zabalza, Beatriz Upna; Rosati, Sergio; Reina Arias, Ramsés Upna (BioMed Central, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal ...
    • Study of compartmentalization in the visna clinical form of small ruminant lentivirus infection in sheep 

      Ramírez, Hugo Upna; Reina Arias, Ramsés Upna; Bertolotti, Luigi; Cenoz, Amaia Upna; Hernández, Mirna Margarita; San Román Aberasturi, Beatriz Upna; Glaría Ezquer, Idoia Upna; Andrés, Ximena de; Crespo, Helena Upna; Jauregui, Paula; Benavides, Julio; Polledo, Laura; Pérez, Valentín; García Marín, Juan F.; Rosati, Sergio; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      Background: A central nervous system (CNS) disease outbreak caused by small ruminant lentiviruses (SRLV) has triggered interest in Spain due to the rapid onset of clinical signs and relevant production losses. In a previous ...