Browsing Artículos de revista IdAB - IdAB Aldizkari artikuluak by Author "Penadés, José R."
Now showing items 1-20 of 22
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B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation
Valle Turrillas, Jaione
; Vergara Irigaray, Marta ; Merino, Nekane ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2007)
Artículo / Artikulua 
Biofilm formation in Staphylococcus aureus is subject to phase variation, and biofilm-negative derivatives emerge sporadically from a biofilm-positive bacterial population. To date, the only known mechanism for generating ... -
Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor
Valle Turrillas, Jaione ; Latasa Osta, Cristina ; Gil Puig, Carmen ; Toledo Arana, Alejandro ; Solano Goñi, Cristina ; Penadés, José R.; Lasa Uzcudun, Íñigo (Public Library of Science, 2012)
Artículo / Artikulua
The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ... -
Bap, a Staphylococcus aureus surface protein involved in biofilm formation
Cucarella, Carme; Solano Goñi, Cristina ; Valle Turrillas, Jaione ; Amorena Zabalza, Beatriz ; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2001)
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Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ... -
Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
Maiques, Elisa; Ubeda, Carles; Campoy Sánchez, Susana; Salvador, Noelia; Lasa Uzcudun, Íñigo ; Novick, Richard P.; Barbé, Jordi; Penadés, José R. (American Society for Microbiology, 2006)
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Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ... -
Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus
Arrizubieta Balerdi, María Jesús; Toledo Arana, Alejandro ; Amorena Zabalza, Beatriz ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2004)
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Bap (biofilm-associated protein) is a 254-kDa staphylococcal surface protein implicated in formation of biofilms by staphylococci isolated from chronic mastitis infections. The presence of potential EF-hand motifs in the ... -
The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation
Toledo Arana, Alejandro ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Arrizubieta Balerdi, María Jesús ; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz ; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2001)
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The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ... -
Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process
Cucarella, Carme; Tormo Más, María Ángeles; Knecht, Erwin; Amorena Zabalza, Beatriz; Lasa Uzcudun, Íñigo ; Foster, Timothy J.; Penadés, José R. (American Society for Microbiology, 2002)
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The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins ... -
Genome-wide antisense transcription drives mRNA processing in bacteria
Lasa Uzcudun, Íñigo ; Toledo Arana, Alejandro ; Dobin, Alexander; Villanueva San Martín, Maite ; Ruiz de los Mozos Aliaga, Igor ; Vergara Irigaray, Marta ; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Gingeras, Thomas R. (National Academy of Sciences, 2011)
Artículo / Artikulua
RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ... -
Killing niche competitors by remote-control bacteriophage induction
Selva, Laura; Viana, David; Regev Yochay, Gili; Trzcinski, Krzysztof; Corpa, Juan Manuel; Lasa Uzcudun, Íñigo ; Novick, Richard P.; Penadés, José R. (National Academy of Sciences, 2009)
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A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by ... -
Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands
Tormo Más, María Ángeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M.; Campoy Sánchez, Susana; Lasa Uzcudun, Íñigo ; Barbé, Jordi; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Nature Research, 2010)
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Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of ∼15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently ... -
Protein A-mediated multicellular behavior in Staphylococcus aureus
Merino, Nekane; Toledo Arana, Alejandro ; Vergara Irigaray, Marta ; Valle Turrillas, Jaione ; Solano Goñi, Cristina ; Calvo, Enrique; Lopez, Juan Antonio; Foster, Timothy J.; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2008)
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The capacity of Staphylococcus aureus to form biofilms on host tissues and implanted medical devices is one of the major virulence traits underlying persistent and chronic infections. The matrix in which S. aureus cells ... -
Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections
Vergara Irigaray, Marta; Valle Turrillas, Jaione ; Merino, Nekane ; Latasa Osta, Cristina ; García Martínez, Begoña ; Ruiz de los Mozos Aliaga, Igor ; Solano Goñi, Cristina ; Toledo Arana, Alejandro ; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2009)
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Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains ... -
RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria
Ferrer, María Desamparados; Quiles Puchalt, Nuria; Harwich, Michael D.; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Barbé, Jordi; Lasa Uzcudun, Íñigo ; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2011)
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Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ... -
Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus
Cucarella, Carme; Tormo Más, María Ángeles; Ubeda, Carles; Trotonda, María Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2004)
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Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ... -
Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer
Maiques, Elisa; Ubeda, Carles; Tormo Más, María Ángeles; Ferrer, María Desamparados; Lasa Uzcudun, Íñigo ; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2007)
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SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one or more of these islands ... -
SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development
Tormo Más, María Ángeles; Martí, Miguel; Valle Turrillas, Jaione ; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2005)
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Staphylococcus epidermidis biofilm formation is associated with the production of the polysaccharide intercellular adhesin (PIA)--poly-N-acetylglucosamine polysaccharide (PNAG) by the products of the icaADBC operon. ... -
SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus
Trotonda, María Pilar; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo ; Penadés, José R. (American Society for Microbiology, 2005)
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The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm formation ... -
Sensory deprivation in Staphylococcus aureus
Villanueva San Martín, Maite ; García Martínez, Begoña ; Valle Turrillas, Jaione ; Rapún Araiz, Beatriz ; Ruiz de los Mozos Aliaga, Igor ; Solano Goñi, Cristina ; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro ; Lasa Uzcudun, Íñigo (Springer Nature, 2018)
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Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ... -
Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals
Taglialegna, Agustina; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Matthews, Steve; Penadés, José R.; Lasa Uzcudun, Íñigo ; Valle Turrillas, Jaione (Public Library of Science, 2016)
Artículo / Artikulua
Major components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in ... -
Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system
Toledo Arana, Alejandro ; Merino, Nekane ; Vergara Irigaray, Marta ; Débarbouillé, Michel; Penadés, José R.; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2005)
Artículo / Artikulua
The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation capacity ...
