Now showing items 1-6 of 6

    • Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus 

      Maiques, Elisa; Ubeda, Carles; Campoy Sánchez, Susana; Salvador, Noelia; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Barbé, Jordi; Penadés, José R. (American Society for Microbiology, 2006)   Artículo / Artikulua  OpenAccess
      Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ...
    • Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands 

      Tormo Más, María Ángeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M.; Campoy Sánchez, Susana; Lasa Uzcudun, Íñigo Upna; Barbé, Jordi; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Nature Research, 2010)   Artículo / Artikulua  OpenAccess
      Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of ∼15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently ...
    • Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica 

      Medina-Ruiz, Laura; Campoy Sánchez, Susana; Latasa Osta, Cristina Upna; Cardenas, Paula; Alonso, Juan Carlos; Barbé, Jordi (American Society for Microbiology, 2010)   Artículo / Artikulua  OpenAccess
      Transcription of the Salmonella enterica recA gene is negatively controlled by the LexA protein, the repressor of the SOS response. The introduction of a mutation (recAo6869) in the LexA binding site, in the promoter region ...
    • RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria 

      Ferrer, María Desamparados; Quiles Puchalt, Nuria; Harwich, Michael D.; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Barbé, Jordi; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2011)   Artículo / Artikulua  OpenAccess
      Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ...
    • Salmonella biofilm development depends on the phosphorylation status of RcsB 

      Latasa Osta, Cristina Upna; García Martínez, Begoña Upna; Echeverz Sarasúa, Maite Upna; Toledo Arana, Alejandro Upna; Valle Turrillas, Jaione Upna; Campoy Sánchez, Susana; García del Portillo, Francisco; Solano Goñi, Cristina Upna; Lasa Uzcudun, Íñigo Upna (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The Rcs phosphorelay pathway is a complex signaling pathway involved in the regulation of many cell surface structures in enteric bacteria. In response to environmental stimuli, the sensor histidine kinase (RcsC) ...
    • A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria 

      Quiles Puchalt, Nuria; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Toledo Arana, Alejandro Upna; Monedero, Vicente; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2013)   Artículo / Artikulua  OpenAccess
      The propagation of bacteriophages and other mobile genetic elements requires exploitation of the phage mechanisms involved in virion assembly and DNA packaging. Here, we identified and characterized four different families ...