• Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine 

      Mancilla, Marcos; Grilló Dolset, María Jesús; Miguel López, María Jesús de; López Goñi, Ignacio; San Román Aberasturi, Beatriz Upna; Zabalza Baranguá, Ana Upna; Moriyón Uría, Ignacio (BioMed Central, 2013)   Artículo / Artikulua  OpenAccess
      Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation ...
    • Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice 

      Soler Lloréns, Pedro; Gil Ramírez, Yolanda Upna; Zabalza Baranguá, Ana Upna; Iriarte, Maite; Conde Álvarez, Raquel; Zúñiga Ripa, Amaia; San Román Aberasturi, Beatriz Upna; Zygmunt, Michel; Vizcaíno, Nieves; Cloeckaert, Axel; Grilló Dolset, María Jesús; Moriyón Uría, Ignacio; López Goñi, Ignacio (BioMed Central, 2014)   Artículo / Artikulua  OpenAccess
      Brucella spp. are Gram-negative bacteria that behave as facultative intracellular parasites of a variety of mammals. This genus includes smooth (S) and rough (R) species that carry S and R lipopolysaccharides (LPS), ...