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dc.contributor.advisorCaballero Murillo, Primitivoes_ES
dc.contributor.advisorLópez Ferber, Migueles_ES
dc.creatorBeperet Arive, Inéses_ES
dc.date.accessioned2015-06-19T12:11:32Z
dc.date.available2015-06-19T12:11:32Z
dc.date.issued2014
dc.date.submitted2014-04-29
dc.identifier.urihttps://hdl.handle.net/2454/17404
dc.description.abstractThis thesis is focused in the ability of different baculovirus species to coinfect a particular host. I investigate whether the co-occlusion of different species is allowed and if it confers some advantage to the viruses, like the generation and maintenance of the viral heterogeneity in ecosystems where two or more virus species are present. Furthermore, as co-infection with different species implies sharing of host resources, we would like to explore the mechanisms (if any) regulating co-infection. Does a virus present in a given cell produce a signal that blocks other virus infection? Can this signal discriminate in function of the relatedness of the genomes? The existence of a temporal window that may allow coinfections and after which the organism becomes refractive to a second infection was analyzed, both in vivo and in vitro. This work also studies, in depth, the factors involved in the establishment of the block to infection by the second virus, such as temporal influences or cellular rearrangements. In a second part, the complete sequence of a Nicaraguan isolate of the SfMNPV is shown and compared with the sequences of this virus that had been previously published. In order to increase our understanding of the virus and its evolution and adaptation to its natural host, we studied the functionality of a unique gene present only in SfMNPV (sf32), some genes suggested to have a host-dependent function (sf68, sf95 and sf138) and a gene undergoing positive selection (sf122).es_ES
dc.format.extent245 p.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.relation.urihttps://biblioteca.unavarra.es/abnetopac/abnetcl.cgi?TITN=434278
dc.subjectAlphabaculoviruseses_ES
dc.subjectMultiple infectionses_ES
dc.subjectSfMNPVes_ES
dc.titleRegulation of multiple infection in alphabaculoviruses: critical factors that determine successes_ES
dc.typeTesis doctoral / Doktoretza tesiaes
dc.typeinfo:eu-repo/semantics/doctoralThesisen
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Producción Agrariaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Nekazaritza Ekoizpena Sailaeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.description.doctorateProgramPrograma Oficial de Doctorado en Biotecnología (RD 1393/2007)es_ES
dc.description.doctorateProgramBioteknologiako Doktoretza Programa Ofiziala (ED 1393/2007)eu


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