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dc.creatorCrespo, Helenaes_ES
dc.creatorBertolotti, Luigies_ES
dc.creatorJuganaru, Magdaes_ES
dc.creatorGlaría Ezquer, Idoiaes_ES
dc.creatorAndrés Cara, Damián dees_ES
dc.creatorAmorena Zabalza, Beatrizes_ES
dc.creatorRosati, Sergioes_ES
dc.creatorReina Arias, Ramséses_ES
dc.date.accessioned2015-09-30T07:35:22Z
dc.date.available2015-09-30T07:35:22Z
dc.date.issued2013
dc.identifier.issn0928-4249 (print)
dc.identifier.issn1297-9716 (electronic)
dc.identifier.urihttps://hdl.handle.net/2454/18319
dc.description.abstractSmall ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal role on the host's innate and adaptative immune responses against parasites by becoming differentially activated. Macrophage heterogeneity can tentatively be classified into classically differentiated macrophages (M1) through stimulation with IFN-gamma displaying an inflammatory profile, or can be alternatively differentiated by stimulation with IL-4/IL-13 into M2 macrophages with homeostatic functions. Since infection by SRLV can modulate macrophage functions we explored here whether ovine and caprine macrophages can be segregated into M1 and M2 populations and whether this differential polarization represents differential susceptibility to SRLV infection. We found that like in human and mouse systems, ovine and caprine macrophages can be differentiated with particular stimuli into M1/M2 subpopulations displaying specific markers. In addition, small ruminant macrophages are plastic since M1 differentiated macrophages can express M2 markers when the stimulus changes from IFN-gamma to IL-4. SRLV replication was restricted in M1 macrophages and increased in M2 differentiated macrophages respectively according to viral production. Identification of the infection pathways in macrophage populations may provide new targets for eliciting appropriate immune responses against SRLV infection.en
dc.description.sponsorshipThis work was funded by grants from CICYT (no. AGL2010-22341-C04-01), and the Government of Navarra (no. IIQ14064.RI1). We acknowledge the Public University of Navarra and CSIC for fellowships and the JAE-contract (HC and RR).en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherBioMed Centralen
dc.relation.ispartofVeterinary Research 2013, 44:83en
dc.rights© 2013 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectMaedi Visnaen
dc.subjectCaprine arthritis-encephalitisen
dc.subjectColony-stimulating factoren
dc.subjectIn-vivoen
dc.subjectAlveolar macrophagesen
dc.subjectMannose receptoren
dc.subjectDendritic cellen
dc.subjectPhylogenetic analysisen
dc.subjectNucleotide-sequenceen
dc.subjectHost-rangeen
dc.titleSmall ruminant macrophage polarization may play a pivotal role on lentiviral infectionen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentIdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1186/1297-9716-44-83
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/AGL2010-22341en
dc.relation.publisherversionhttps://dx.doi.org/10.1186/1297-9716-44-83
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: IIQ14064.RI1
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa


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© 2013 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © 2013 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.