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dc.creatorTaglialegna, Agustinaes_ES
dc.creatorNavarro, Susannaes_ES
dc.creatorVentura, Salvadores_ES
dc.creatorGarnett, James A.es_ES
dc.creatorMatthews, Stevees_ES
dc.creatorPenadés, José R.es_ES
dc.creatorLasa Uzcudun, Íñigoes_ES
dc.creatorValle Turrillas, Jaionees_ES
dc.date.accessioned2016-11-04T16:17:59Z
dc.date.available2016-11-04T16:17:59Z
dc.date.issued2016
dc.identifier.issn1553-7366 (Print)
dc.identifier.issn1553-7374 (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/22580
dc.description.abstractMajor components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in several staphylococcal species forms functional amyloid aggregates to build the biofilm matrix in response to specific environmental conditions. Under low Ca2+ concentrations and acidic pH, Bap is processed and forms insoluble aggregates with amyloidogenic properties. When the Ca2+ concentration increases, metal-coordinated Bap adopts a structurally more stable conformation and as a consequence, the N-terminal region is unable to assemble into amyloid aggregates. The control of Bap cleavage and assembly helps to regulate biofilm matrix development as a function of environmental changes.en
dc.description.sponsorshipThis research was supported by the Spanish Ministry of Economy and Competitiveness grants AGL2011-23954, BIO2014-53530-R and BFU2013-44763-P. JV was supported by Ramon y Cajal (RYC-2009-03948) contract from the Spanish Ministry of Economy and Competitiveness.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPLoS Pathogens 12(6): e1005711en
dc.rights© 2016 Taglialegna et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectStaphylococcus aureusen
dc.subjectBacterial biofilmsen
dc.subjectAmyloid proteinsen
dc.subjectExtracellular matrixen
dc.titleStaphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signalsen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.contributor.departmentIdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.doi10.1371/journal.ppat.1005711
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/AGL2011-23954en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/BIO2014-53530-Ren
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/BFU2013-44763en
dc.relation.publisherversionhttps://dx.doi.org/10.1371/journal.ppat.1005711
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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© 2016 Taglialegna et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
credited.
Except where otherwise noted, this item's license is described as © 2016 Taglialegna et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.