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    An effort to make sense of antisense transcription in bacteria

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    RNA Biology_Lasa.pdf (177.8Kb)
    Date
    2012
    Author
    Lasa Uzcudun, Íñigo Upna Orcid
    Toledo Arana, Alejandro Upna Orcid
    Gingeras, Thomas R. 
    Version
    Acceso abierto / Sarbide irekia
    Type
    Artículo / Artikulua
    Version
    Versión aceptada / Onetsi den bertsioa
    Project Identifier
    ES/6PN/BIO2008-05284 
    ES/6PN/BIO2011-30503 
    ES/6PN/BFU2011-23222 
    Impact
     
     
     
    10.4161/rna.21167
     
     
     
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    Abstract
    Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcript ... [++]
    Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed. [--]
    Subject
    Overlapping transcription, RNase III, RNA processing, Bacteria, Transcriptome
     
    Publisher
    Taylor & Francis
    Published in
    RNA Biology, Volume 9, 2012, Issue 8
    Description
    This is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.
    Departament
    IdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
    Publisher version
    https://dx.doi.org/10.4161/rna.21167
    URI
    https://hdl.handle.net/2454/22581
    Sponsorship
    A.T.-A. is recipient of “Ramon y Cajal” contracts from the Spanish Ministry of Science and Innovation. This research was supported by grants ERA-NET Pathogenomics (PIM2010EPA-00606), BIO2008-05284-C02, BIO2011-30503-C02 and BFU2011-23222 from Spanish Ministry of Economy and Competitiveness.
    Appears in Collections
    • Artículos de revista - Aldizkari artikuluak [4253]
    • Artículos de revista IdAB - IdAB Aldizkari artikuluak [185]
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