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dc.creatorLasa Uzcudun, Íñigoes_ES
dc.creatorToledo Arana, Alejandroes_ES
dc.creatorGingeras, Thomas R.es_ES
dc.date.accessioned2016-11-04T16:49:03Z
dc.date.available2016-11-04T16:49:03Z
dc.date.issued2012
dc.identifier.issn1547-6286 (Print)
dc.identifier.issn1555-8584 (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/22581
dc.descriptionThis is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.en
dc.description.abstractAnalysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed.en
dc.description.sponsorshipA.T.-A. is recipient of “Ramon y Cajal” contracts from the Spanish Ministry of Science and Innovation. This research was supported by grants ERA-NET Pathogenomics (PIM2010EPA-00606), BIO2008-05284-C02, BIO2011-30503-C02 and BFU2011-23222 from Spanish Ministry of Economy and Competitiveness.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherTaylor & Francisen
dc.relation.ispartofRNA Biology, Volume 9, 2012, Issue 8en
dc.rights© 2012 Landes Bioscienceen
dc.subjectOverlapping transcriptionen
dc.subjectRNase IIIen
dc.subjectRNA processingen
dc.subjectBacteriaen
dc.subjectTranscriptomeen
dc.titleAn effort to make sense of antisense transcription in bacteriaen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.contributor.departmentIdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.doi10.4161/rna.21167
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/BIO2008-05284en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/BIO2011-30503en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/BFU2011-23222en
dc.relation.publisherversionhttps://dx.doi.org/10.4161/rna.21167
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen


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