Evidence for a 200 gene ribosome and rRNA biosynthesis (rrb) regulon in fungi
Fecha
2006Versión
Acceso abierto / Sarbide irekia
Tipo
Contribución a congreso / Biltzarrerako ekarpena
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
nodoi-noplumx
|
Resumen
Two challenges of the post genomic era are 1) the need to assign functions to
as yet uncharacterized gene products, and 2) the requirement to understand
how the expression profiles of large sets of genes are regulated in response to
changing environments. Towards these aims, we have used transcriptional
profiling analysis to identify and characterize a large set (over 200 genes) of
transcrip ...
[++]
Two challenges of the post genomic era are 1) the need to assign functions to
as yet uncharacterized gene products, and 2) the requirement to understand
how the expression profiles of large sets of genes are regulated in response to
changing environments. Towards these aims, we have used transcriptional
profiling analysis to identify and characterize a large set (over 200 genes) of
transcriptionally co-regulated genes whose products are involved in rRNA
and ribosome biosynthesis. Many of the genes within this set were previously
unknown with regards to their function. This RRB regulon is distinct from
the ribosomal protein (RP) regulon, and is characterized by a unique pair of
conserved promoter motifs. The organization of the RRB regulon appears to
be evolutionarily conserved at least from S. cerevisiae to S. pombe. The strategies
used to identify and characterize this gene set can be widely used in other
organisms to help fulfill the two needs outlined above. [--]
Materias
rRNA biosyntehsis,
Ribosome biosynthesis
Editor
Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
Publicado en
Antonio G. Pisabarro and Lucía Ramírez (eds.): VI Meeting on Genetics and Cellular Biology of Basidiomycetes (GCBB-VI). Pamplona: Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, 2006.
Notas
Resumen de la conferencia presentada al VI Meeting on Genetics and Cellular Biology of Basidiomycetes (GCBB-VI), organizado por y celebrado en la Universidad Pública de Navarra el 3-6 de junio de 2005.