Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment

Celay Leoz, Ion; Blanco Luquin, Idoia; Lázcoz, Paula; Rotinen Díaz, Mirja Sofia; Castresana, Javier S.; Encío Martínez, Ignacio

doi:10.1371/journal.pone.0062771

dc.creator	Celay Leoz, Ion	es_ES
dc.creator	Blanco Luquin, Idoia	es_ES
dc.creator	Lázcoz, Paula	es_ES
dc.creator	Rotinen Díaz, Mirja Sofia	es_ES
dc.creator	Castresana, Javier S.	es_ES
dc.creator	Encío Martínez, Ignacio	es_ES
dc.date.accessioned	2018-09-06T12:20:21Z
dc.date.available	2018-09-06T12:20:21Z
dc.date.issued	2013
dc.identifier.issn	1932-6203
dc.identifier.uri	https://hdl.handle.net/2454/30552
dc.description.abstract	To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers induced apoptosis and reduced cell density as a result of cell differentiation and/or apoptosis. Flow cytometry revealed that 9-cis RA induced apoptosis more effectively than ATRA. The expression profile of apoptosis and survival pathways was cell line specific and depended on the isomer used.	en
dc.description.sponsorship	This work was supported by grants from the Departmento de Salud, Gobierno de Navarra, Pamplona, and from the Fondo de Investigación Sanitaria (PI08/1849), Madrid, Spain.	en
dc.format.mimetype	application/pdf	en
dc.language.iso	eng	en
dc.publisher	Public Library of Science	en
dc.relation.ispartof	Plos One, 8(5): e62771	en
dc.rights	© 2013 Celay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	en
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/
dc.subject	Retinoic acid	en
dc.subject	Neuroblastoma	en
dc.subject	Apoptosis	en
dc.title	Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.identifier.doi	10.1371/journal.pone.0062771
dc.relation.publisherversion	https://doi.org/10.1371/journal.pone.0062771
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dc.contributor.funder	Gobierno de Navarra / Nafarroako Gobernua	es

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© 2013 Celay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

La licencia del ítem se describe como © 2013 Celay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.