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dc.creatorJiménez Alonso, Sandraes_ES
dc.creatorGascón, Soniaes_ES
dc.creatorLuquin, Asunciónes_ES
dc.creatorLaguna, Marianoes_ES
dc.creatorAncín Azpilicueta, Carmenes_ES
dc.creatorRodríguez Yoldi, María Jesúses_ES
dc.date.accessioned2018-09-06T12:20:23Z
dc.date.available2018-09-06T12:20:23Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/2454/30557
dc.description.abstractThe in vitro antiproliferative and antioxidant effects of different fractions of Rosa canina hips on human colon cancer cell lines (Caco-2) was studied. The compounds tested were total extract (fraction 1), vitamin C (fraction 2), neutral polyphenols (fraction 3) and acidic polyphenols (fraction 4). All the extracts showed high cytotoxicity after 72 h, both low and high concentrations. The flow cytometric analysis revealed that all the fractions produce disturbances in the cell cycle resulting in a concomitant cell death by an apoptotic pathway. Changes in the redox status of Caco-2 cells in response to Rosa canina hips were determined. Cells were exposed to hydrogen peroxide in presence of plant fractions and the production of Reactive Oxygen Species (ROS) was significantly decreased. Therefore, our data demonstrate that rosehip extracts are a powerful antioxidant that produces an antiproliferative effect in Caco-2 cells. Therefore, these results predict a promising future for Rosa canina as a therapeutic agent. Thus, this natural plant could be an effective component of functional foods addressed towards colorectal carcinoma.en
dc.description.sponsorshipThis study was supported by the projects: the Ministry of Science and Innovation (SAF2013-41651), funding from Aragón Regional Government (A-32) and CIBER (Centros de Investigación Biomédica en Red) Sub-program (CIBERobn, CB06/03/1012,) by the Instituto de Salud Carlos III and Proyecto ELENA, EFA 220/11 ELENA.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPlos One, 11(7): e0159136en
dc.rights© 2016 Jiménez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectRosa canina hipsen
dc.subjectColon canceren
dc.subjectCaco-2 cellsen
dc.subjectAntiproliferative effecten
dc.subjectAntioxidant effecten
dc.titleRosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon canceren
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Química Aplicadaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Kimika Aplikatua Sailaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1371/journal.pone.0159136
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2013-41651en
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0159136
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2016 Jiménez et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
credited.
Except where otherwise noted, this item's license is described as © 2016 Jiménez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.