Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study

Ibáñez Sanz, Gemma; Díez Villanueva, Anna; Vilorio Marqués, Laura; Gracia, Esther; Aragonés, Nuria; Olmedo Requena, Rocío; Llorca, Javier; Vidán, Juana; Amiano, Pilar; Nos, Pilar; Fernández Tardón, Guillermo; Rada, Ricardo; Chirlaque, María Dolores; Guinó, Elisabet; Dávila Batista, Verónica; Castaño Vinyals, Gemma; Pérez Gómez, Beatriz; Mirón Pozo, Benito; Dierssen Sotos, Trinidad; Etxeberria Andueza, Jaione; Molinuevo, Amaia; Álvarez Cuenllas, Begoña; Kogevinas, Manolis; Pollán, Marina; Moreno, Víctor

doi:10.1038/s41598-018-20349-6

dc.creator	Ibáñez Sanz, Gemma	es_ES
dc.creator	Díez Villanueva, Anna	es_ES
dc.creator	Vilorio Marqués, Laura	es_ES
dc.creator	Gracia, Esther	es_ES
dc.creator	Aragonés, Nuria	es_ES
dc.creator	Olmedo Requena, Rocío	es_ES
dc.creator	Llorca, Javier	es_ES
dc.creator	Vidán, Juana	es_ES
dc.creator	Amiano, Pilar	es_ES
dc.creator	Nos, Pilar	es_ES
dc.creator	Fernández Tardón, Guillermo	es_ES
dc.creator	Rada, Ricardo	es_ES
dc.creator	Chirlaque, María Dolores	es_ES
dc.creator	Guinó, Elisabet	es_ES
dc.creator	Dávila Batista, Verónica	es_ES
dc.creator	Castaño Vinyals, Gemma	es_ES
dc.creator	Pérez Gómez, Beatriz	es_ES
dc.creator	Mirón Pozo, Benito	es_ES
dc.creator	Dierssen Sotos, Trinidad	es_ES
dc.creator	Etxeberria Andueza, Jaione	es_ES
dc.creator	Molinuevo, Amaia	es_ES
dc.creator	Álvarez Cuenllas, Begoña	es_ES
dc.creator	Kogevinas, Manolis	es_ES
dc.creator	Pollán, Marina	es_ES
dc.creator	Moreno, Víctor	es_ES
dc.date.accessioned	2018-09-19T09:37:43Z
dc.date.available	2018-09-19T09:37:43Z
dc.date.issued	2018
dc.identifier.issn	2045-2322 (Electronic)
dc.identifier.uri	https://hdl.handle.net/2454/30721
dc.description.abstract	A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28–0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47–1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62–0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs.	en
dc.description.sponsorship	This work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds –‘a way to build Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castilla y León (grant LE22A10–2); the Consejería de Salud of the Junta de Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP 00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants FOOD-CT-2006-036224-HIWATE; the Fundación Científica Asociación Española Contra el Cáncer (AECC); the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action BM1206 Eucolongene.	en
dc.format.extent	8 p.
dc.format.mimetype	application/pdf	en
dc.language.iso	eng	en
dc.publisher	Springer Nature	en
dc.relation.ispartof	Scientific Reports, (2018) 8:2040	en
dc.rights	© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Colorectal cancer	en
dc.subject	Glucosamine	en
dc.subject	Chondroitin sulphate	en
dc.title	Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.contributor.department	Estadística e Investigación Operativa	es_ES
dc.contributor.department	Estatistika eta Ikerketa Operatiboa	eu
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.identifier.doi	10.1038/s41598-018-20349-6
dc.relation.publisherversion	https://doi.org/10.1038/s41598-018-20349-6
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es

Ficheros en el ítem

Nombre:: 33_Ibanez_PossibleRole.pdf
Tamaño:: 918.2Kb
Formato:: PDF

Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted
by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder.

La licencia del ítem se describe como © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.