Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial
Fecha
2017Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
ES/1PE/DEP2016-78377-R
Impacto
|
10.1186/s13063-017-2117-y
Resumen
Background: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes
(T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention
program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of
developing T2D and (2) to identify the profile of microRNA in ci ...
[++]
Background: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes
(T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention
program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of
developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood
mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary
intervention program including exercise.
Methods: A total of 84 children, aged 8–12 years, with a high risk of T2D will be included and randomly assigned
to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education
and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle
education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including
warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be
evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin
A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA
expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory
fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry).
Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve
their cardiovascular health and to reduce the comorbidities associated with obesity. [--]
Materias
Type-2 diabetes,
Children,
Exercise,
Family based lifestyle intervention program,
miRNA,
Ectopic fat
Editor
BioMed Central
Publicado en
Trials, (2017) 18:372
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
The current project was supported by the Spanish Ministry of Industry and
Competitiveness (DEP2016-78377-R), by “Fondos Estructurales de la Unión
Europea (FEDER), Una manera de hacer Europa.” and by the University of the
Basque Country (GIU14/21). This work was also supported by grants from
Spanish Ministry of Economy and Competitiveness (RYC-2010-05957, RYC-2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/
03329) and by the Education, Linguistic Policy and Culture Department of
the Government of the Basque Country (PRE_2016_1_0057).
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