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dc.creatorNúñez, Marinaes_ES
dc.creatorUrdaneta, Elenaes_ES
dc.creatorSantidrián, Santiagoes_ES
dc.identifier.issn0007-1145 (Print)
dc.identifier.issn1475-2662 (Electronic)
dc.description.abstractThe malnutrition caused by liver cirrhosis (LC) often worsens the course of the disease. Patients affected by LC often have a low bioavailability of the anabolic liver peptide insulin-like growth factor (IGF)-I. The present study was undertaken to investigate the effect of low doses of IGF-I on the nutritional status and in vivo jejunal transport of d-galactose in anatomically, pathologically and biochemically confirmed moderate, non-ascitic, cirrhotic rats. LC was experimentally induced in growing rats by inhalation of CCl4 and addition of phenobarbital to drinking water. Both the nutritional status, as evaluated by N balance, and in vivo intestinal transport of d-galactose, were significantly impaired in cirrhotic rats. As compared with healthy rats, administration of 20μg human recombinant IGF-I/kg body weight for 14d to cirrhotic rats significantly improved N balance variables and restored in vivo intestinal transport of the sugar. However, IGF-I had no effect on the steatorrhoea associated with LC. These results suggest that low doses of IGF-I may have beneficial effects on the malnutrition associated with moderate LC.en
dc.format.extent9 p.
dc.publisherCambridge University Pressen
dc.relation.ispartofBritish Journal of Nutrition (2003), 90, 929–937en
dc.rights© The Authors 2003en
dc.subjectEffect of insulin-like growth factor-Ien
dc.subjectNitrogen balanceen
dc.subjectIntestinal absorptionen
dc.titleEffect of insulin-like growth factor-I on nitrogen balance and intestinal galactose transport in rats with moderate liver cirrhosisen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentCiencias del Medio Naturales_ES
dc.contributor.departmentNatura Ingurunearen Zientziakeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión publicada / Argitaratu den bertsioaes

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