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    Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus

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    Date
    2006
    Author
    Maiques, Elisa 
    Ubeda, Carles 
    Campoy Sánchez, Susana 
    Salvador, Noelia 
    Lasa Uzcudun, Íñigo Upna Orcid
    Novick, Richard P. 
    Barbé, Jordi 
    Penadés, José R. 
    Version
    Acceso abierto / Sarbide irekia
    Type
    Artículo / Artikulua
    Version
    Versión publicada / Argitaratu den bertsioa
    Impact
     
     
     
    10.1128/jb.188.7.2726-2729.2006
     
     
     
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    Abstract
    Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA ... [++]
    Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, β-lactam-mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors. [--]
    Subject
    Beta-lactams, Staphylococcus aureus, SOS response, Horizontal transfer, Virulence factors
     
    Publisher
    American Society for Microbiology
    Published in
    Journal of Bacteriology, Apr. 2006, Vol. 188, No. 7, p. 2726–2729
    Departament
    IdAB - Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
    Publisher version
    https://doi.org/10.1128/jb.188.7.2726-2729.2006
    URI
    https://hdl.handle.net/2454/32031
    Sponsorship
    This work was supported by grants BIO2002-04542-C02-01 and BIO2005-08399-C02-02 from the Comisión Interministerial de Ciencia y Tecnología (C.I.C.Y.T.), grants from the Cardenal Herrera-CEU University, the Conselleria de Agricultura, Pesca i Alimentació (CAPiA), and the Generalitat Valenciana (CTIDIA/2002/62, CTESPP/2003/027, and AE04-8) to J.R.P., and a grant from the MEC (AGL2005-03574/GAN) to J.B. Fellowship support for C.U. from CAPiA and for E.M. from the Cardenal Herrera-CEU University is gratefully acknowledged.
    Appears in Collections
    • Artículos de revista IdAB - IdAB Aldizkari artikuluak [189]
    • Artículos de revista - Aldizkari artikuluak [4586]
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