Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
Fecha
2006Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1128/jb.188.7.2726-2729.2006
Resumen
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus
aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of
pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response
in S. aureus, characterized by the activation of the RecA and LexA ...
[++]
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus
aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of
pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response
in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the
SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction
in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used
fluoroquinolone antibiotics, β-lactam-mediated phage induction also resulted in replication and high-frequency
transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the
unintended consequence of promoting the spread of bacterial virulence factors. [--]
Materias
Beta-lactams,
Staphylococcus aureus,
SOS response,
Horizontal transfer,
Virulence factors
Editor
American Society for Microbiology
Publicado en
Journal of Bacteriology, Apr. 2006, Vol. 188, No. 7, p. 2726–2729
Departamento
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
Versión del editor
Entidades Financiadoras
This work was supported by grants BIO2002-04542-C02-01 and
BIO2005-08399-C02-02 from the Comisión Interministerial de Ciencia
y Tecnología (C.I.C.Y.T.), grants from the Cardenal Herrera-CEU
University, the Conselleria de Agricultura, Pesca i Alimentació (CAPiA), and
the Generalitat Valenciana (CTIDIA/2002/62, CTESPP/2003/027, and
AE04-8) to J.R.P., and a grant from the MEC (AGL2005-03574/GAN) to
J.B. Fellowship support for C.U. from CAPiA and for E.M. from the
Cardenal Herrera-CEU University is gratefully acknowledged.