Ovine TRIM5α can restrict visna/maedi virus

Jauregui, Paula; Crespo, Helena; Glaría Ezquer, Idoia; Luján, Lluís; Contreras, A.; Rosati, Sergio; Andrés Cara, Damián de; Amorena Zabalza, Beatriz; Towers, G. J.; Reina Arias, Ramsés

doi:10.1128/jvi.00440-12

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Date

2012

Author

Andrés Cara, Damián de

Amorena Zabalza, Beatriz

Towers, G. J.

Reina Arias, Ramsés

Version

Acceso abierto / Sarbide irekia

Type

Artículo / Artikulua

Version

Versión publicada / Argitaratu den bertsioa

Impact

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Abstract

The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthe ... [++]

Subject

TRIM5α, Visna/maedi virus, Sheep, Goats

Publisher

American Society for Microbiology

Published in

Journal of Virology, September 2012 Volume 86 Number 17, p. 9504–9509

Departament

Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua

Publisher version

https://doi.org/10.1128/jvi.00440-12

URI

https://hdl.handle.net/2454/32035

Sponsorship

This work was supported by grants from CICYT (no. AGL2010-22341- C04-01), the Government of Navarra (no. IIQ14064.RI1), the UK Medical Research Centre, and the UK National Institute of Health Research UCL/UCLH Comprehensive Biomedical Research Centre and fellowships from the Spanish Ministry of Science and Innovation (P.J.) and the Wellcome Trust (G.J.T.).