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dc.creatorFernández-Real, Jose Manueles_ES
dc.creatorIzquierdo Redín, Mikeles_ES
dc.creatorMoreno-Navarrete, Jose Maríaes_ES
dc.creatorGorostiaga Ayestarán, Estebanes_ES
dc.creatorOrtega, Francisco B.es_ES
dc.creatorMartínez Labari, Cristinaes_ES
dc.creatorIdoate, Fernandoes_ES
dc.creatorRicart, Wifredoes_ES
dc.creatorIbáñez Santos, Javieres_ES
dc.date.accessioned2019-06-20T08:02:49Z
dc.date.available2019-06-20T08:02:49Z
dc.date.issued2009
dc.identifier.issn0307-0565 (Print)
dc.identifier.issn1476-5497 (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/33459
dc.description.abstractBackground: Circulating soluble transferrin receptor (sTfR) has been recently found to be associated negatively with insulin sensitivity. Objective: To evaluate circulating sTfR concentration after changing insulin sensitivity in obese individuals. Design: Circulating sTfR concentration was evaluated after diet-induced weight loss in obese women (diet (D) group, n=8); after diet-induced weight loss plus resistance training (D+RT group, n=11); and after follow-up without weight loss (control (C) group, n=7). Results: After 16 weeks, insulin sensitivity (HOMA (Homeostasis Model Assessment) value) significantly improved in parallel to weight loss (−7.3%) and reduced total fat mass (evaluated using magnetic resonance imaging) in the D group. Thigh muscle mass decreased significantly (P=0.03). Serum sTfR concentration did not change significantly. In the D+RT group, weight loss (−8.7%) and improvement of insulin sensitivity were of similar magnitude. Thigh muscle mass was preserved (P=0.8). Serum sTfR concentration decreased significantly (P=0.001). Interestingly, higher the thigh muscle volume after weight loss, higher the decrease in circulating sTfR concentration. We also found that higher the increases in leg force at week 16, higher the decrease in circulating sTfR concentration in all individuals as a whole. No significant changes were observed in insulin sensitivity, sTfR concentration or thigh muscle mass in the C group. Conclusion: These findings suggest a long-term regulation of serum sTfR concentration by exercise-induced improvement of insulin ensitivity in obese individuals.en
dc.format.extent17 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherSpringer Natureen
dc.relation.ispartofInternational Journal of Obesity (2009) 33, 768–774en
dc.rights© 2009 Macmillan Publishers Limited. All rights reserved.en
dc.subjectWeight lossen
dc.subjectIronen
dc.subjectTransferrin receptoren
dc.subjectInsulin sensitivityen
dc.titleCirculating soluble transferrin receptor concentration decreases after exercise-induced improvement of insulin sensitivity in obese individualsen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ciencias de la Saludes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Osasun Zientziak Sailaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1038/ijo.2009.99
dc.relation.publisherversionhttps://doi.org/10.1038/ijo.2009.99
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.type.versionVersión aceptada / Onetsi den bertsioaes


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