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dc.creatorLabayen Goñi, Idoiaes_ES
dc.creatorRuiz, Jonatan R.es_ES
dc.creatorArenaza, Lidees_ES
dc.creatorMedrano Echeverría, Maríaes_ES
dc.creatorTobalina, Ignacioes_ES
dc.creatorGracia-Marco, Luises_ES
dc.creatorOrtega, Francisco B.es_ES
dc.creatorRodríguez Vigil, Beatrizes_ES
dc.date.accessioned2019-06-25T08:05:47Z
dc.date.available2019-06-25T08:05:47Z
dc.date.issued2018
dc.identifier.issn1530-0447
dc.identifier.urihttps://hdl.handle.net/2454/33496
dc.description.abstractObjectives: To examine the influence of non-alcoholic fatty liver disease (NAFLD) and hepatic fat content on bone mineral density (BMD), and to investigate whether the relationship between NAFLD and BMD is independent of lifestyle factors related to BMD. Methods: Hepatic fat content (magnetic resonance imaging), BMD, lean mass index, total and abdominal fat mass (dual-energy-X-ray absorptiometry), moderate to vigorous physical activity (MVPA) (accelerometry), and calcium and vitamin D intake (two 24 h recalls) were measured in 115 children with overweight/obesity aged 10.6 +/- 1.1 years old. Result: Children with NAFLD had lower BMD than children without NAFLD regardless of sex, puberty stage, lean mass index, fat mass, MVPA, and calcium and vitamin D intake (0.89 +/- 0.01 vs. 0.93 +/- 0.01 g/cm(2) for NAFLD and non-NAFLD, respectively, P < 0.01). Higher hepatic fat content was significantly associated with lower BMD regardless of confounders (adjusted P < 0.05). Conclusions: Findings of the current study suggest that hepatic fat accumulation is associated with decreased BMD independently of adiposity, and regardless of those lifestyle factors closely related to bone mineral accrual in children. These results may have implication in the clinical management of children with overweight/obesity given the high prevalence of pediatric NAFLD.en
dc.description.sponsorshipThe current project was supported by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), by "Fondos Estructurales de la Union Europea (FEDER), Una manera de hacer Europa", and by the University of the Basque Country (GIU14/21). This work was also supported by grants from Spanish Ministry of Economy and Competitiveness (RYC-2010-05957; RYC-2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/03329), and by the Education, Linguistic Policy and Culture Department of the Government of the Basque Country (PRE_2016_1_0057), and also by "Programa de Captacion de Talento - UGR Fellows" as part of "Plan Propio" of the University of Granada (Spain).en
dc.format.extent20 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherSpringer Natureen
dc.relation.ispartofPediatric Research, 84 (5), 684-688en
dc.rights© 2018, Springer Natureen
dc.subjectOverweight childrenen
dc.subjectObese childrenen
dc.subjectHepatic fat contenten
dc.subjectBone mineral densityen
dc.titleHepatic fat content and bone mineral density in children with overweight/obesityen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODes_ES
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1038/s41390-018-0129-2
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/DEP2016-78377-Ren
dc.relation.publisherversionhttps://doi.org/10.1038/s41390-018-0129-2
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.type.versionVersión aceptada / Onetsi den bertsioaes


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