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dc.creatorMármol, Inéses_ES
dc.creatorJiménez Moreno, Nereaes_ES
dc.creatorAncín Azpilicueta, Carmenes_ES
dc.creatorOsada, Jesúses_ES
dc.creatorCerrada, Elenaes_ES
dc.creatorRodríguez Yoldi, María Jesúses_ES
dc.date.accessioned2020-05-12T11:15:24Z
dc.date.available2020-05-12T11:15:24Z
dc.date.issued2020
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/2454/36863
dc.description.abstractGiven the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from Rosa canina have been successfully tested against several cancer models, including colon cancer. Moreover, gold derivatives are a promising alternative to the current platinum-based drugs commonly used in CRC chemotherapy due to their lack of affinity for DNA. Herein we have investigated the antitumor potential of a drug combination made of acidic polyphenols extracted from R. canina and the gold complex (Au(C≡C-2-NC5H4) (PTA)) in Caco-2 cell line as a model of CRC. The combination triggered strong apoptosis mediated by a blockage of the autophagic flux, which might be a consequence of a reactive oxygen species (ROS) increase and mitochondrial dysfunctionality. Our results suggest that the clinical application of plant polyphenols might enhance the anticancer effect of metallodrugs and reduce drug exposure time and therefore its side effects.en
dc.description.sponsorshipThis work was supported by grants from Ministerio de Economía y Competitividad, Gobierno de España (SAF2016-75441-R and CTQ2016-75816-C2-1-P), CIBERobn (CB06/03/1012), Gobierno de Aragón (B16-17R and E07-17R, Fondos FEDER 'Otra manera de hacer Europa'), SUDOE (Redvalue, SOE1/PI/E0123) and Proyecto ELENA (EFA 220/11 ELENA).en
dc.format.extent12 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofAntioxidants, 2020, 9 (1), 17en
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectApoptosisen
dc.subjectAutophagyen
dc.subjectColorectal canceren
dc.subjectRosehipen
dc.subjectGold complexen
dc.subjectROSen
dc.titleA combination of Rosa canina extracts and gold complex favors apoptosis of Caco-2 cells by increasing oxidative stress and mitochondrial dysfunctionen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Cienciases_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Zientziak Sailaeu
dc.contributor.departmentUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. InaMat - Institute for Advanced Materialses_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.3390/antiox9010017
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2016-75441-Ren
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/CTQ2016-75816en
dc.relation.publisherversionhttps://doi.org/10.3390/antiox9010017
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license
Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license