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dc.creatorCabello Olmo, Miriames_ES
dc.creatorOneca, Maríaes_ES
dc.creatorTorre Hernández, Palomaes_ES
dc.creatorSainz, Neiraes_ES
dc.creatorMoreno Aliaga, María J.es_ES
dc.creatorGuruceaga, Elizabethes_ES
dc.creatorDíaz, Jesús Vicentees_ES
dc.creatorEncío Martínez, Ignacioes_ES
dc.creatorBarajas Vélez, Miguel Ángeles_ES
dc.creatorAraña Ciordia, Miriames_ES
dc.date.accessioned2020-05-19T06:57:54Z
dc.date.available2020-05-19T06:57:54Z
dc.date.issued2019
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/2454/36912
dc.description.abstractType 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received increasing attention in T2D etiology and progression. In the present study, we have explored the effect of long-term supplementation with a non-dairy fermented food product (FFP) in Zucker Diabetic and Fatty (ZDF) rats T2D model. The supplementation with FFP induced an improvement in glucose homeostasis according to the results obtained from fasting blood glucose levels, glucose tolerance test, and pancreatic function. Importantly, a significantly reduced intestinal glucose absorption was found in the FFP-treated rats. Supplemented animals also showed a greater survival suggesting a better health status as a result of the FFP intake. Some dissimilarities have been observed in the gut microbiota population between control and FFP-treated rats, and interestingly a tendency for better cardiometabolic markers values was appreciated in this group. However, no significant differences were observed in body weight, body composition, or food intake between groups. These findings suggest that FFP induced gut microbiota modifications in ZDF rats that improved glucose metabolism and protected from T2D development.en
dc.description.sponsorshipThis research was funded by grant from Advanced Innovation & Technology Corporation (ADItech Corp, Department of Economic Development, Navarre Government) [Reference: PT022 SIMDIACOL]. Miriam Cabello-Olmo was granted by the Industrial PhD program (Navarre Government) [Reference: 001114082016000011].en
dc.format.extent23 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofNutrients, 2019, 11 (10), 2530en
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDiabetesen
dc.subjectFermented fooden
dc.subjectGut microbiotaen
dc.subjectLactic acid bacteriaen
dc.subjectPostbioticen
dc.subjectProbioticen
dc.titleA fermented food product containing lactic acid bacteria protects ZDF rats from the development of type 2 diabetesen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentCienciases_ES
dc.contributor.departmentZientziakeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.3390/nu11102530
dc.relation.publisherversionhttps://doi.org/10.3390/nu11102530
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY)
La licencia del ítem se describe como © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)

El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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